{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:23:43Z","timestamp":1740126223686,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K10966"],"award-info":[{"award-number":["15K10966"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of this study was to evaluate the impact of cerebral blood flow (<jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>) recovery obtained from brain single\u2010photon emission computed tomography (<jats:styled-content style=\"fixed-case\">SPECT<\/jats:styled-content>) images on postoperative outcome after aneurysmal subarachnoid haemorrhage (<jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content>). Twenty\u2010nine patients who had undergone surgical clipping for ruptured anterior communicating artery aneurysms were analyzed prospectively. Routine measurements of <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> were performed using technetium\u201099\u00a0m hexamethyl propyleneamine oxine <jats:styled-content style=\"fixed-case\">SPECT<\/jats:styled-content> on days 4 and 14 after <jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content>. Regional voxel data analyzed by three dimensional stereotactic surface projection (3D\u2010<jats:styled-content style=\"fixed-case\">SSP<\/jats:styled-content>) were compared between patients and age\u2010matched normal database (<jats:styled-content style=\"fixed-case\">NDB<\/jats:styled-content>). In 3D\u2010<jats:styled-content style=\"fixed-case\">SSP<\/jats:styled-content> analysis of all patients, cortical hypoperfusion around the surgical site in bilateral frontal lobes was evident on day 4 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05 vs <jats:styled-content style=\"fixed-case\">NDB<\/jats:styled-content>), which was improved significantly on day 14. However, the recovery was less complete in patients with poor clinical grades (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) and presenting symptoms attributable to delayed cerebral ischaemia (<jats:styled-content style=\"fixed-case\">DCI<\/jats:styled-content>) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) than those without. Multivariate analysis showed that patients with mild to moderate <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> recovery (relative Z\u2010score differences of &lt;4) (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.014; odds ratio, 2.5; 95% confidence interval, 1.93\u20133.31) was independently associated with poor functional outcome at 3\u00a0months. We conclude that reduced <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> recovery detected by serial 3D\u2010<jats:styled-content style=\"fixed-case\">SSP SPECT<\/jats:styled-content> image analyses can be a potential predictor of poor prognosis in postoperative patients after <jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1440-1681.12867","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T19:56:38Z","timestamp":1507233398000},"page":"127-132","source":"Crossref","is-referenced-by-count":3,"title":["Reduced <scp>CBF<\/scp> recovery detected by longitudinal 3D\u2010<scp>SSP SPECT<\/scp> analyses predicts outcome of postoperative patients after subarachnoid haemorrhage"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7770-379X","authenticated-orcid":false,"given":"Tatsushi","family":"Mutoh","sequence":"first","affiliation":[{"name":"Department of 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