{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:40:22Z","timestamp":1787013622945,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Advanced glycation end products (\n                    <jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content>\n                    s) are destructive compounds with pathogenic importance in age\u2010related chronic diseases. Zinc has antioxidant, anti\u2010inflammatory and anti\u2010apoptotic potential. This study aimed to summarize effects of zinc on\n                    <jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content>\n                    formation and\n                    <jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content>\n                    \u2010induced damaging agents. Pubmed, Google scholar, Web of Sciences, and Scopus databases were searched. There was no limitation for publication date. English language original articles (in vitro, experimental and human studies) which examined the effect of external zinc on\n                    <jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content>\n                    formation,\n                    <jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content>\n                    \u2010induced apoptosis, or oxidative stress in mammals were included. To review the effect of zinc on\n                    <jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content>\n                    generation, the search keywords were as follows: \u201czinc\u201d in title and \u201c\n                    <jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content>\n                    s\u201d or \u201cmethylglyoxal\u201d or \u201cpentosidine\u201d or \u201ccarboxymethyllysine\u201d or \u201cglucosylation\u201d or \u201ccarbonyl stress\u201d or \u201c\n                    <jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content>\n                    s\u2010induced apoptosis or oxidative stress or inflammation\u201d in title\/abstract. In total, 90 titles and abstracts were identified. Fifty\u2010two studies were screened after duplicates were removed. Six articles were chosen for review following analysis of both titles and summaries. Finally, based on intensive critical appraisal, 5 articles were included in the study. The evidence presented indicates that zinc has anti\u2010glycation, anti\u2010oxidative and anti\u2010apoptotic effects. Zinc insufficiency may stimulate\n                    <jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content>\n                    s formation. Whereas, zinc supplementation could inhibit formation of\n                    <jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content>\n                    s,\n                    <jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content>\n                    \u2010induced cell apoptosis and oxidative stress status, and protein carbonyl formation possibly through various signalling pathways.\n                  <\/jats:p>","DOI":"10.1111\/1440-1681.12904","type":"journal-article","created":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T09:39:19Z","timestamp":1512725959000},"page":"491-498","source":"Crossref","is-referenced-by-count":21,"title":["Zinc against advanced glycation end products"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6249-4462","authenticated-orcid":false,"given":"Sorayya","family":"Kheirouri","sequence":"first","affiliation":[{"name":"Department of Nutrition Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Alizadeh","sequence":"additional","affiliation":[{"name":"Department of Nutrition Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Maleki","sequence":"additional","affiliation":[{"name":"Department of Nutrition Tabriz University of Medical Sciences Tabriz 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