{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T20:52:01Z","timestamp":1779396721045,"version":"3.53.1"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T00:00:00Z","timestamp":1519948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study aimed to ascertain if atropine is useful for suppressing the pain suffered during four\u2010dimensional hysterosalpingo\u2010contrast sonography (4D\u2010HyCoSy) when assessing infertility in women. A total of 252 patients were divided into 2 groups to receive or not receive atropine (0.5\u00a0mg) injection 30\u00a0minutes before 4D\u2010HyCoSy. Pain was evaluated using a numerical rating scale (<jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content>): during 4D\u2010HyCoSy; upon 2\u2010dimensional transvaginal sonography; before catheter insertion; upon insertion and fixation of the catheter into the uterine cavity; 30\u00a0minutes after 4D\u2010HyCoSy. According to the degree of patency of Fallopian tubes, the 6 patterns observed were integrated further into 3 patient groups: all\u2010negative (both Fallopian tubes were negative), positive\u2010and\u2010negative (one Fallopian tube showed patency and the other showed stenosis or non\u2010patency), and all\u2010positive (both Fallopian tubes showed stenosis or non\u2010patency). We compared the <jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content> scores and prevalence of side\u2010effects other than pain between the atropine\u2010injection and non\u2010atropine\u2010injection groups within the three groups mentioned above. The <jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content> score showed no significant differences among the groups at any time point (all <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). The different prevalence of side\u2010effects other than pain was significant between the atropine\u2010injection and atropine\u2010non\u2010injection groups (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.012). These data suggest that atropine does not reduce pain in patients during 4D\u2010HyCoSy. However, atropine may reduce the prevalence of other side\u2010effects during 4D\u2010HyCoSy, which needs a further, large, prospective, multi\u2010cohort study to verify.<\/jats:p>","DOI":"10.1111\/1440-1681.12919","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T16:07:13Z","timestamp":1517328433000},"page":"1334-1340","source":"Crossref","is-referenced-by-count":3,"title":["Use of atropine in four\u2010dimensional hysterosalpingo\u2010contrast sonography: Does it suppress pain during infertility examination?"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9183-956X","authenticated-orcid":false,"given":"Yunfei","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Ultrasound Shanghai General Hospital of Nanjing Medical University  Shanghai China"},{"name":"Department of Ultrasound Jiangsu Province Hospital of Traditional Chinese Medicine  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianfang","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Shanghai General Hospital of Nanjing Medical University  Shanghai China"},{"name":"Department of Ultrasound Shanghai First People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Shanghai First People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqiu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Jiangsu Province Hospital of Traditional Chinese Medicine  Nanjing Jiangsu 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