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In this study, we generated <jats:italic>Ptrf<\/jats:italic> transgenic mice to explore its function <jats:italic>in vivo<\/jats:italic>. Compared with wild\u2010type (<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>) mice, we found that the <jats:italic>Ptrf<\/jats:italic> transgenic mice showed obesity with an increased level of <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> (alanine aminotransferase) and <jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content> (aspartate transaminase). <jats:italic>Ptrf<\/jats:italic> transgenic mice exhibited severe fat degeneration and a higher degree of fat accumulation in the liver compared with <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> mice. Consistently, we found that the expression of the fat synthesis gene, <jats:italic>Fasn<\/jats:italic>, was increased in the liver of <jats:italic>Ptrf<\/jats:italic> transgenic mice. Thus, <jats:italic>Ptrf<\/jats:italic> transgenic mice would be a good model for investigating the molecular mechanism and therapeutic targets of obesity and fatty liver associated diseases.<\/jats:p>","DOI":"10.1111\/1440-1681.12920","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T18:44:41Z","timestamp":1517337881000},"page":"704-710","source":"Crossref","is-referenced-by-count":5,"title":["<i>Ptrf<\/i> transgenic mice exhibit obesity and fatty liver"],"prefix":"10.1111","volume":"45","author":[{"given":"Qian","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Aging Research Hangzhou Normal University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Bai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Human Disease Comparative Medicine of the Ministry of Health Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and 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