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In order to conduct the study, we used adult male <jats:italic>Wistar albino<\/jats:italic> rats (n\u00a0=\u00a030; 4\u00a0weeks old; 100\u00a0\u00b1\u00a015\u00a0g body weight). Hyperhomocysteinaemia (<jats:styled-content style=\"fixed-case\">HH<\/jats:styled-content>cy) in these animals was achieved by dietary manipulation. For 4\u00a0weeks, the animals were fed with a standard rodent chow (control, <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>), a diet enriched in methionine with no deficiency in B vitamins (i.e., folic acid, B6 and B12) (<jats:styled-content style=\"fixed-case\">HMNV<\/jats:styled-content>) or a diet enriched in methionine and deficient in B vitamins (<jats:styled-content style=\"fixed-case\">HMLV<\/jats:styled-content>). After 28\u00a0days of dietary manipulation, all animals were killed. The rat hearts were isolated and retrogradely perfused according to the Langendorff technique at a gradually increasing perfusion pressure. We found a negative correlation between elevated serum Hcy and total body and heart weight. The maximum rate of left ventricular pressure development was significantly increased in the <jats:styled-content style=\"fixed-case\">HMNV<\/jats:styled-content> group compared with in the other groups. Systolic left ventricular pressure was significantly changed in all groups. <jats:styled-content style=\"fixed-case\">HH<\/jats:styled-content>cy induces remodelling of the cardiac tissues, as moderate <jats:styled-content style=\"fixed-case\">HH<\/jats:styled-content>cy is associated with more prominent interstitial and perivascular fibrosis. Our results suggest that a high methionine diet without vitamin B complex causes profound negative effects associated with <jats:styled-content style=\"fixed-case\">HH<\/jats:styled-content>cy.<\/jats:p>","DOI":"10.1111\/1440-1681.12930","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T15:00:43Z","timestamp":1520348443000},"page":"683-693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Vitamin B complex mitigates cardiac dysfunction in high\u2010methionine diet\u2010induced hyperhomocysteinemia"],"prefix":"10.1111","volume":"45","author":[{"given":"Jovana","family":"Jeremic","sequence":"first","affiliation":[{"name":"Department of Pharmacy Faculty of Medical Sciences University of Kragujevac  Kragujevac Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Nikolic Turnic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy 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