{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:59:51Z","timestamp":1790006391113,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Long non\u2010coding <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s) participate in the modulation of cardiac hypertrophy, and they represent potential therapeutic targets in cardiovascular disease. We investigated the expression profiles of selected lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s in peripheral blood mononuclear cells of patients with essential hypertension in relation to left ventricular hypertrophy. We assessed the expression levels of the lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s <jats:italic><jats:styled-content style=\"fixed-case\">MHRT<\/jats:styled-content><\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">FENDRR<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">CARMEN<\/jats:styled-content><\/jats:italic> using real\u2010time reverse transcription polymerase chain reaction. Hypertensive patients showed significantly higher <jats:italic><jats:styled-content style=\"fixed-case\">MHRT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FENDRR<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">CARMEN<\/jats:styled-content><\/jats:italic> expression levels compared with healthy controls. In addition, we observed significant negative correlations of <jats:italic><jats:styled-content style=\"fixed-case\">MHRT<\/jats:styled-content><\/jats:italic> (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.323, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) and <jats:italic><jats:styled-content style=\"fixed-case\">FENDRR<\/jats:styled-content><\/jats:italic> (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.380, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) and a positive correlation of <jats:italic><jats:styled-content style=\"fixed-case\">CARMEN<\/jats:styled-content><\/jats:italic> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.458, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) expression levels with left ventricular mass index. Our data reveal that the lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s <jats:italic><jats:styled-content style=\"fixed-case\">MHRT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FENDRR<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">CARMEN<\/jats:styled-content><\/jats:italic> show distinct expression profiles in hypertensive patients and they possibly represent candidate therapeutic targets in hypertensive heart disease.<\/jats:p>","DOI":"10.1111\/1440-1681.12997","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T13:11:31Z","timestamp":1529413891000},"page":"1213-1217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The long non\u2010coding <scp>RNA<\/scp>s <i><scp>MHRT<\/scp><\/i>,<i><scp>FENDRR<\/scp><\/i> and <i><scp>CARMEN<\/scp><\/i>, their expression levels in peripheral blood mononuclear cells in patients with essential hypertension and their relation to heart hypertrophy"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3160-1856","authenticated-orcid":false,"given":"Joanna E.","family":"Kontaraki","sequence":"first","affiliation":[{"name":"Molecular Cardiology Laboratory School of Medicine University of Crete  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Marketou","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heraklion University Hospital  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George E.","family":"Kochiadakis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heraklion University Hospital  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyros","family":"Maragkoudakis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heraklion University Hospital  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Konstantinou","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heraklion University Hospital  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panos E.","family":"Vardas","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heraklion University Hospital  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fragiskos I.","family":"Parthenakis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heraklion University Hospital  Heraklion 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