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Moreover, reduction in nitric oxide (<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>) bioavailability is related to hypertensive pregnancy and H<jats:sub>2<\/jats:sub>S may interact with<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>, modulating its production. We aimed to investigate the Na<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>effects in hypertension\u2010in\u2010pregnancy and also in feto\u2010placental parameters. Female Wistar rats (200\u2010250\u00a0g) were mated and desoxycorticosterone acetate injections followed by replacement of water by 0.9% saline solution were used to induce hypertensive pregnancy. Rats were divided into four groups: normal pregnant (Norm\u2010Preg), pregnant + Na<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>(Preg+Na<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>), hypertensive pregnant (<jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>\u2010Preg) and<jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>\u2010Preg+Na<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>. Systolic blood pressure was increased in<jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>\u2010Preg and this increase was blunted in<jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>\u2010Preg+Na<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>. Fetal and placental weights were decreased in<jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>\u2010Preg animals, while fetal growth restriction was improved in<jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>\u2010Preg+Na<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>. Placental weight was lower in<jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>\u2010Preg+Na<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>than in<jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>\u2010Preg; however, placental efficiency was re\u2010established in<jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>\u2010Preg+Na<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>rats. We observed that a partial contribution of placental<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>, but not changes in anti\u2010angiogenic factors may mediate the increases in placental efficiency in<jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>\u2010Preg+Na<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>\u2010Preg presented thoracic aorta hyperreactivity to phenylephrine while Na<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>treatment blunted this hyperreactivity, which seems not to be related to<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\u2010mediated relaxation induced by acetylcholine. Therefore, changes in vascular responsiveness promoted by Na<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>treatment may underlie the beneficial effects in systolic blood pressure and feto\u2010placental parameters in our study.<\/jats:p>","DOI":"10.1111\/1440-1681.13000","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T16:13:29Z","timestamp":1529597609000},"page":"1118-1127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Increases in placental nitric oxide, but not nitric oxide\u2010mediated relaxation, underlie the improvement in placental efficiency and antihypertensive effects of hydrogen sulphide donor in hypertensive pregnancy"],"prefix":"10.1111","volume":"45","author":[{"given":"Jose S.","family":"Possomato\u2010Vieira","sequence":"first","affiliation":[{"name":"Department of Pharmacology Biosciences Institute of Botucatu S\u00e3o Paulo State University \u2013 UNESP Botucatu Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica S.","family":"Chimini","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Biosciences Institute of Botucatu S\u00e3o Paulo State University \u2013 UNESP Botucatu Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L. 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