{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:50:42Z","timestamp":1792590642994,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T00:00:00Z","timestamp":1535932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><\/jats:sec><jats:sec><jats:label\/><jats:p>Diabetes mellitus and hypertension are diseases that are strongly correlated. A major factor in this correlation is the renin\u2013angiotensin system (<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>), with the peptide angiotensin II being a key component. This study analyzed the impact of Angiotensin Type 1 receptor (<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>1R) and Angiotension Type 2 receptor (<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>2R) in atrial function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main methods<\/jats:title><jats:p>To perform the experiments, Wistar Kyoto rats (<jats:styled-content style=\"fixed-case\">WKY<\/jats:styled-content>), diabetic streptozotocin\u2010induced<jats:styled-content style=\"fixed-case\">WKY<\/jats:styled-content>rats and spontaneously hypertensive rats (<jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content>) were used, and stimulation of cardiovascular function was done by means of the following drugs: angiotensin<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, novokinin and the antagonists losartan and<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>123177. We also measured the systolic blood pressure (<jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An increase in<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>1R function was observed in diabetic and hypertensive rats (18% in right atria [<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>] and 11% in left atria [<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>]). We also observed an increase in calcium release from the endoplasmic reticulum in right atria of diabetic rats (31%) and in right atria of hypertensive rats (35%). On the other hand, a decreased response of<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>2R in diabetic and hypertensive rats was observed, this decreased response was greater in hypertensive rats (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>, 10%;<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>, 12%). These results have demonstrated a dysfunction of the RAS that may contribute to the common dysfunctions of the cardiovascular system in diabetic and hypertensive rats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1440-1681.13019","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T07:34:21Z","timestamp":1532936061000},"page":"1274-1285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Function of AT1 and AT2 receptors in atrial contractions from spontaneous hypertensive and diabetic\u2010induced streptozotocin rats"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0846-3208","authenticated-orcid":false,"given":"Diego Castro","family":"Musial","sequence":"first","affiliation":[{"name":"Departamento de Farmacolog\u00eda Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Centro de Ci\u00eancias da Sa\u00fade e do Desporto Universidade 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