{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:23:14Z","timestamp":1792786994156,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T00:00:00Z","timestamp":1537056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Natural Science Funding of China","award":["81670882, 81770926"],"award-info":[{"award-number":["81670882, 81770926"]}]},{"name":"Natural Science Funding of Zhejiang Province","award":["LR18H160003"],"award-info":[{"award-number":["LR18H160003"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Diabetic retinopathy (\n                    <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>\n                    ) is one of the most frequently occurring microvascular complications of diabetes. Recent evidence indicates that epidermal growth factor receptors (\n                    <jats:styled-content style=\"fixed-case\">EGFR<\/jats:styled-content>\n                    s) are critical pathogenic players in non\u2010neoplastic diseases, including diabetic cardiomyopathy and\n                    <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>\n                    . However, the precise pathogenic mechanism of\n                    <jats:styled-content style=\"fixed-case\">EGFR<\/jats:styled-content>\n                    in\n                    <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>\n                    has yet to be fully understood. In this study, we developed a type 1 diabetic early\u2010stage retinopathy mouse model using injections of streptozotocin and an oxygen\u2010induced end\u2010stage diabetic retinopathy (\n                    <jats:styled-content style=\"fixed-case\">OIR<\/jats:styled-content>\n                    ) model characterized by hypoxia\u2010induced revascularization. We tested the hypothesis that the pathogenesis of\n                    <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>\n                    can be reduced by the classic\n                    <jats:styled-content style=\"fixed-case\">EGFR<\/jats:styled-content>\n                    inhibitor,\n                    <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>\n                    1478, in the mouse models. Our data indicated that treatment of\n                    <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>\n                    1478 prevented retinal dysfunction, and reduced impairment of retinal structures as well as mitochondrial structures in retinal blood vessels in diabetic mice. Furthermore,\n                    <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>\n                    1478 reduced neovascular tufts formation but had no effects on revascularization at the avascular sites when compared to untreated littermates in the\n                    <jats:styled-content style=\"fixed-case\">OIR<\/jats:styled-content>\n                    model. Our findings provide strong evidence that\n                    <jats:styled-content style=\"fixed-case\">EGFR<\/jats:styled-content>\n                    critically promoted retinal dysfunction, retinal structural impairment, and retinal vascular abnormalities in models of\n                    <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>\n                    . We conclude that\n                    <jats:styled-content style=\"fixed-case\">EGFR<\/jats:styled-content>\n                    can be a potential important therapeutic target for treatment of\n                    <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/1440-1681.13029","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T02:43:01Z","timestamp":1537152181000},"page":"75-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["<scp>EGFR<\/scp>\n                    inhibitor,\n                    <scp>AG<\/scp>\n                    1478, inhibits inflammatory infiltration and angiogenesis in mice with diabetic retinopathy"],"prefix":"10.1111","volume":"46","author":[{"given":"Xin","family":"Ju","sequence":"first","affiliation":[{"name":"Chemical Biology Research Center School of 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