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Omega\u20103 (\u03c9\u20103) fatty acids (<jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>s), eicosapentaenoic acid (<jats:styled-content style=\"fixed-case\">EPA<\/jats:styled-content>) and docosahexaenoic acid (<jats:styled-content style=\"fixed-case\">DHA<\/jats:styled-content>), of fish oil are beneficial for the prevention of <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>. The effect can be ascribed to anti\u2010inflammatory, vasodilating, antiarrhythmic, antihypertensive activities and lowering of triacyl glycerol level. The American Heart Association advises two fish meals per week in subjects without <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content> or supplementation of 1 g of <jats:styled-content style=\"fixed-case\">EPA<\/jats:styled-content> plus <jats:styled-content style=\"fixed-case\">DHA<\/jats:styled-content> per day in subjects with <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>. Despite the beneficial effects of <jats:styled-content style=\"fixed-case\">EPA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DHA<\/jats:styled-content> reported in some of the clinical trials, results of many others were inconsistent that can be ascribed to short duration of studies, low doses of \u03c9\u20103 <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>s, variations in the <jats:styled-content style=\"fixed-case\">EPA<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\">DHA<\/jats:styled-content> ratio, selection of patients with different risk factors or interaction of \u03c9\u20103 <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>s with drugs used in the therapy. Therefore, well designed clinical trials in various populations are warranted. This article discusses the current situation and future prospective of \u03c9\u20103 <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1440-1681.13034","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T19:45:19Z","timestamp":1537386319000},"page":"11-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Omega\u20103 fatty acids in coronary heart disease: Recent updates and future perspectives"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9915-846X","authenticated-orcid":false,"given":"Thekkuttuparambil A.","family":"Ajith","sequence":"first","affiliation":[{"name":"Department of Biochemistry Amala Institute of Medical Sciences Thrissur Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thankamani 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