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The purpose of this study was to further examine the possible mechanism underlying the effect of inhibition of Syk by <jats:styled-content style=\"fixed-case\">BAY<\/jats:styled-content>61\u20103606 via <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB activity at the level of nuclear translocation regarding the production of vasodilator and proinflammatory mediators in lipopolysaccharide (<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>) (septic)\u2010 and <jats:styled-content style=\"fixed-case\">ZYM<\/jats:styled-content> (non\u2010septic)\u2010induced shock. Administration of <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> (10\u00a0mg\/kg, ip) or <jats:styled-content style=\"fixed-case\">ZYM<\/jats:styled-content> (500\u00a0mg\/kg, ip) to male Wistar rats decreased mean arterial pressure and increased heart rate that was associated with an increase in the activities of cyclooxygenase and nitric oxide synthase, tumour necrosis factor\u2010\u03b1, and interleukin\u20108 levels, and <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB activation and nuclear translocation in sera and\/or cardiovascular and renal tissues. <jats:styled-content style=\"fixed-case\">BAY<\/jats:styled-content>61\u20103606 (3\u00a0mg\/kg, ip), the selective Syk inhibitor, given 1\u00a0hour after <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010 or <jats:styled-content style=\"fixed-case\">ZYM<\/jats:styled-content> injection reversed all the above\u2010mentioned effects. These results suggest that Syk contributes to the <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010 or <jats:styled-content style=\"fixed-case\">ZYM<\/jats:styled-content>\u2010induced hypotension and inflammation associated with transactivation of <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB in septic and non\u2010septic shock.<\/jats:p>","DOI":"10.1111\/1440-1681.13045","type":"journal-article","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T22:10:09Z","timestamp":1540246209000},"page":"173-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["<scp>NF<\/scp>\u2010\u03baB activation mediates <scp>LPS<\/scp>\u2010or zymosan\u2010induced hypotension and inflammation reversed by <scp>BAY<\/scp>61\u20103606, a selective Syk inhibitor, in rat models of septic and non\u2010septic 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