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For this reason, Pimozide has been widely studied as a potential anticancer treatment, and satisfactory results in melanoma, central nervous system tumours, osteosarcoma, neuroblastoma, myeloproliferative neoplasms, breast, lung, prostate, ovarian, colorectal, pancreatic, and hepatocellular carcinoma have been showed. Moreover, advantages as clinical use approved by the Food and Drug Administration (\n                    <jats:styled-content style=\"fixed-case\">FDA<\/jats:styled-content>\n                    ), high clinical safety, low side effects, and reasonable price have stimulated the treatment with Pimozide instead of other agents. The action mechanism remains unclear, but three\n                    <jats:italic>vias<\/jats:italic>\n                    associated to cancer stem cell (\n                    <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>\n                    ) hypothesis show that Pimozide: (a) blocks\n                    <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>\n                    features, as epithelial\u2010to\u2010mesenchymal transition (\n                    <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content>\n                    ), through inhibition of Wnt\u2010\u03b2\/catenin signalling; (b) acts as an inhibitor of signal transducer and activator of transcription (\n                    <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>\n                    \u20103 and 5), pathway which is activated and up\u2010regulated in\n                    <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>\n                    s; (c) inhibits ubiquitine specific protease (\n                    <jats:styled-content style=\"fixed-case\">USP<\/jats:styled-content>\n                    1) and\n                    <jats:styled-content style=\"fixed-case\">WD<\/jats:styled-content>\n                    repeat\u2010containing protein 48 (\n                    <jats:styled-content style=\"fixed-case\">WDR<\/jats:styled-content>\n                    48), that are proteins responsible to inhibit the differentiation and to maintain the cell in an undifferentiated state. Based on this perspective, the aim of this manuscript is to review the antineoplastic role of Pimozide during tumorigenesis and its potential to revert the process of undifferentiation and proliferation of\n                    <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>\n                    through different\n                    <jats:italic>vias<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/1440-1681.13049","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T14:23:37Z","timestamp":1541082217000},"page":"116-125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Inhibition of cancer stem cells promoted by Pimozide"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4030-9398","authenticated-orcid":false,"given":"Jussara Maria","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Postgraduate Program in Dentistry Federal University of Santa Catarina Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Am\u00e1lia Barcellos","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences Federal University of Santa Catarina Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Riet Correa","family":"Rivero","sequence":"additional","affiliation":[{"name":"Department of Pathology Federal University of Santa Catarina Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mabel Mariela Rodr\u00edguez","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences Federal University of Santa Catarina Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"16","volume-title":"World cancer report","author":"World Health Organization","year":"2014"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Analysis of gene expression and chemoresistance of CD133\u00a0+\u00a0 cancer stem cells in glioblastoma","volume":"12","author":"Liu G","year":"2006","journal-title":"Mol Cancer"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.43.1.43"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2008.01163.x"},{"issue":"1","key":"e_1_2_7_6_1","first-page":"45","article-title":"Psychotropic drugs as potential antitumor agents: a selective screening study","volume":"62","author":"Driscoll JS","year":"1978","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00156-2"},{"key":"e_1_2_7_8_1","unstructured":"Pharmaceuticals G.Leaflet ORAP\u00ae(Pimozide) Tablets. 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