{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:25:06Z","timestamp":1783445106585,"version":"3.54.6"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Haemophilia A and B are rarely occurring X chromosome\u2010linked congenital coagulation disorders dominated by spontaneous joint bleedings and chronic synovitis, leading to development of haemophilic arthropathy (HA). Progranulin (PGRN) is a growth factor with anti\u2010inflammatory and immunomodulatory properties. PGRN is an important molecule in the pathogenesis of osteoarthritis (OA) and rheumatological disorders. This study was aimed at investigating the potential role of PGRN in the mechanisms underlying the pathogenesis of HA. The serum levels of PGRN were measured by enzyme\u2010linked immunosorbent assay (ELISA) in patients with end\u2010stage knee joint HA (n\u00a0=\u00a020) and end\u2010stage primary knee joint OA (n\u00a0=\u00a020) who met the inclusion and exclusion criteria. The clinical and radiological assessment of disease severity was evaluated by the Knee Society Score (KSS) and Kellgren\u2010Lawrence scale. Median PGRN levels in HA patients was 349.1\u00a0ng\/mL (232.8\u2013415.6\u00a0ng\/mL) and in OA patients 148.3\u00a0ng\/mL (112.1\u2010275.3\u00a0ng\/mL) with statistically significant differences between both groups (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.015). Further analysis revealed no correlation between PGRN levels and any of the patient demographics and clinical parameters. This study demonstrates increased PGRN serum levels in patients with HA and provides new insights into the mechanisms underlying the pathogenesis of HA indicating a new potential target for therapeutic intervention.\n                  <\/jats:p>","DOI":"10.1111\/1440-1681.13054","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T05:05:39Z","timestamp":1543467939000},"page":"373-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Increased serum levels of progranulin (PGRN) in patients with haemophilic arthropathy"],"prefix":"10.1111","volume":"46","author":[{"given":"Andrzej","family":"Kotela","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Traumatology 1st Faculty of Medicine Medical University of Warsaw Warsaw Poland"},{"name":"Department of Orthopaedics and Traumatology Central Clinical Hospital of the Ministry of the Interior and Administration Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Wojdasiewicz","sequence":"additional","affiliation":[{"name":"Department of General and Experimental Pathology Centre for Preclinical Research and Technology (CePT) Medical University of Warsaw Warsaw Poland"},{"name":"Department of Rehabilitation Eleonora Reicher National Institute of Geriatrics, Rheumatology and Rehabilitation Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"\u0141\u0119gosz","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology 1st Faculty of Medicine Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2437-8908","authenticated-orcid":false,"given":"Sylwia","family":"Sarzy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology 1st Faculty of Medicine Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Drela","sequence":"additional","affiliation":[{"name":"NeuroRepair Department Mossakowski Medical Research Centre Polish Academy of Sciences Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Pulik","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology 1st Faculty of Medicine Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Kaleta","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology 1st Faculty of Medicine Tadeusz Or\u0142owski Transplantation Institute Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Kniotek","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology 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