{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:35:12Z","timestamp":1789788912488,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:00:00Z","timestamp":1548892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Pulpitis suppressed the level of let\u20107c\u20105p that promotes osteogenesis and bone formation by repressing HMGA2. In the current study, the function of let\u20107c\u20105p in the inflammation and osteogenesis in dental pulp stem cells (DPSCs) was explored. The level of let\u20107c\u20105p in DPSCs was up\u2010regulated, and the cells were subjected to lipopolysaccharide (LPS) to induce inflammation. The effect of let\u20107c\u20105p on cell proliferation potential, osteogenic differentiation potential, and activity of HMGA2\/PI3K\/Akt pathway was detected. The administration of LPS suppressed the cell proliferation of DPSCs and suppressed calcium deposition, activity of alkaline phosphatase (ALP), and levels of OCN, OPN, OSX, MSX2, and RUNX2 in inflamed DPSCs. The impaired osteogenic differentiation of inflamed DPSCs was associated with the increased levels of HMGA2, p\u2010PI3K, and p\u2010Akt. In let\u20107c\u20105p\u2010overexpressed inflamed DPSCs, the proliferation and osteogenic differentiation potential of DPSCs were restored, and the activation of HMGA2\/PI3K\/Akt signalling was inhibited. In rat pulpitis models, the injection of let\u20107c\u20105p agomir restored the osteogenic differentiation potential of dental pulp cells and inhibited HMGA2\/PI3K\/Akt signalling. The findings demonstrated the anti\u2010inflammation and pro\u2010osteogenesis effect of let\u20107c\u20105p during the attack of pulpitis, which depended on the inhibition of HMGA2\/PI3K\/Akt signalling.<\/jats:p>","DOI":"10.1111\/1440-1681.13059","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T22:26:36Z","timestamp":1545431196000},"page":"389-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["MicroRNA let\u20107c\u20105p promotes osteogenic differentiation of dental pulp stem cells by inhibiting lipopolysaccharide\u2010induced inflammation via HMGA2\/PI3K\/Akt signal blockade"],"prefix":"10.1111","volume":"46","author":[{"given":"Hao","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Endodontics School of Stomatology Jilin University Changchun 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