{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:32:26Z","timestamp":1788654746008,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We investigated the potential augmenting effects of 19 clinically available antidepressants on noradrenaline (<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>)\u2010induced contractions in guinea pig urethra smooth muscle (<jats:styled-content style=\"fixed-case\">USM<\/jats:styled-content>). Concentration\u2010response curves for <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>\u2010induced contractions in guinea pig <jats:styled-content style=\"fixed-case\">USM<\/jats:styled-content> strips were obtained in the absence or presence of selected antidepressants. Desipramine, an active metabolite of imipramine, produced a contraction and potentiated <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>\u2010induced contraction at the distal urethra without affecting the proximal urethra. Further, nortriptyline and amoxapine, tricyclic antidepressants, produced a contraction and potentiated <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>\u2010induced contraction at the distal urethra. <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>\u2010induced contraction was unaffected or reduced by imipramine, clomipramine, trimipramine, and amitriptyline at the proximal and distal urethra. Maprotiline, a tetracyclic antidepressant, potentiated <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>\u2010induced contraction at the distal urethra. <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>\u2010induced contraction was unaffected by mianserin at the proximal and distal urethra. Paroxetine, a selective serotonin reuptake inhibitor (<jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content>), potentiated <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>\u2010induced contraction at the distal urethra, while <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>\u2010induced contraction was unaffected by fluvoxamine, sertraline, and escitalopram at the proximal and distal urethra. Milnacipran, a serotonin\u2010noradrenaline reuptake inhibitor (<jats:styled-content style=\"fixed-case\">SNRI<\/jats:styled-content>), potentiated <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>\u2010induced contraction at the proximal and distal urethra, whereas duloxetine potentiated it at the distal urethra. Mirtazapine slightly inhibited <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>\u2010induced contraction at the distal urethra. Aripiprazole and sulpiride did not affect <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>\u2010induced contractions at the proximal nor distal urethra. Trazodone inhibited <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>\u2010induced contraction at both urethras. Desipramine, nortriptyline, amoxapine, maprotiline, paroxetine, milnacipran, and duloxetine likely induce urinary disturbance by increasing urethral resistance and augmenting <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>\u2010induced contraction, which should be carefully considered when delivering guidance for drug administration to patients.<\/jats:p>","DOI":"10.1111\/1440-1681.13072","type":"journal-article","created":{"date-parts":[[2019,2,9]],"date-time":"2019-02-09T01:03:50Z","timestamp":1549674230000},"page":"444-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of the potentiating effects of antidepressants on the contractile response to noradrenaline in guinea pig urethra smooth muscles"],"prefix":"10.1111","volume":"46","author":[{"given":"Keisuke","family":"Obara","sequence":"first","affiliation":[{"name":"Department of Chemical Pharmacology Faculty of Pharmaceutical Sciences Toho University Funabashi\u2010City Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Imanaka","sequence":"additional","affiliation":[{"name":"Department of Chemical Pharmacology Faculty of Pharmaceutical Sciences Toho University Funabashi\u2010City Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroka","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Department of Chemical Pharmacology Faculty of Pharmaceutical Sciences Toho University Funabashi\u2010City Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Yamaki","sequence":"additional","affiliation":[{"name":"Department of Chemical Pharmacology Faculty of Pharmaceutical Sciences Toho University Funabashi\u2010City Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmaceutical Sciences Toho University Funabashi\u2010City Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yoshio","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmaceutical Sciences Toho University Funabashi\u2010City Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8341-3809","authenticated-orcid":false,"given":"Yoshio","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Chemical Pharmacology Faculty of Pharmaceutical Sciences Toho University Funabashi\u2010City Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association.Diagnostic and Statistical Manual of Mental Disorders: DSM\u20105 5th ed.Washington DC:American Psychiatric Association;2013.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_6_3_1","unstructured":"World Health Organization.The global burden of disease: 2004 update[internet].Geneva Switzerland:WHO Press 2008. 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