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Now, it is widely accepted that cortical bone and trabecular bone are two different compartments, and should be treated as separate compartments in pathological processes, such as fracture healing. It is currently unknown whether PTH and the activation of \u03b2\u2010catenin signalling would demonstrate different effects on cortical bone and trabecular bone healing. In the current study, single 0.6\u2010mm cortex holes were made in the femur metaphysis and diaphysis of mice, and then, PTH application and \u03b2\u2010catenin activation were used to observe the promoting effect on bone healing. The effects of \u03b2\u2010catenin and PTH signalling on fracture healing were observed by X\u2010ray and CT at 3, 6, and 14\u00a0days after fracture, and the levels of \u03b2\u2010catenin were detected by RT\u2010PCR assay, and the number of specific antigen\u2010positive cells of BRDU, OCN, RUNX2 was counted by immunohistochemical staining. While \u03b2\u2010catenin activation and PTH were found to demonstrate similar effects on accelerating metaphyseal bone healing, activation of \u03b2\u2010catenin showed a more striking effect than PTH on promoting diaphyseal bone healing. These findings might be helpful for selecting proper medication to accelerate fracture healing of different bone compartments.<\/jats:p>","DOI":"10.1111\/1440-1681.13088","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T18:45:30Z","timestamp":1553539530000},"page":"652-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Different effects of Wnt\/\u03b2\u2010catenin activation and parathyroid hormone on diaphyseal and metaphyseal in the early phase of femur bone healing of mice"],"prefix":"10.1111","volume":"46","author":[{"given":"Daocheng","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Trauma, Burn and Combined injury, Department of War Wound Rescue Skills Training, Base of Army Health Service Training Army Medical University Chongqing 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