{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:24:10Z","timestamp":1747182250855,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["HL116729","HL138023","2HL118067"],"award-info":[{"award-number":["HL116729","HL138023","2HL118067"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["GRNT25860041"],"award-info":[{"award-number":["GRNT25860041"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obg\u2010like <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>ase 1 (<jats:styled-content style=\"fixed-case\">OLA<\/jats:styled-content>1) that possesses both <jats:styled-content style=\"fixed-case\">GTP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content> hydrolyzing activities has been shown to be involved in translational regulation of cancer cell growth and survival. Also, <jats:styled-content style=\"fixed-case\">GSK<\/jats:styled-content>3\u03b2 signalling has been implicated in cardiac development and disease. However, the role of <jats:styled-content style=\"fixed-case\">OLA<\/jats:styled-content>1 in pathological cardiac hypertrophy is unknown. We sought to understand the mechanism by which <jats:styled-content style=\"fixed-case\">OLA<\/jats:styled-content>1 regulates <jats:styled-content style=\"fixed-case\">GSK<\/jats:styled-content>3\u03b2\u2010\u03b2\u2010Catenin signalling and its functional significance in angiotensin\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">ANG II<\/jats:styled-content>)\u2010induced cardiac hypertrophic response. <jats:styled-content style=\"fixed-case\">OLA<\/jats:styled-content>1 function and its endogenous interaction with <jats:styled-content style=\"fixed-case\">GSK<\/jats:styled-content>3\u03b2\/\u03b2\u2010catenin signalling in cultured human ventricular cardiomyocytes (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>16 cells) and mouse hearts (in vivo) was evaluated with\/without <jats:styled-content style=\"fixed-case\">ANG II<\/jats:styled-content>\u2010stimulated hypertrophic response. <jats:styled-content style=\"fixed-case\">ANG II<\/jats:styled-content> administration in mice increases myocardial <jats:styled-content style=\"fixed-case\">OLA<\/jats:styled-content>1 protein expression with a corresponding increase in <jats:styled-content style=\"fixed-case\">GSK<\/jats:styled-content>3\u03b2 phosphorylation and decrease in \u03b2\u2010Catenin phosphorylation. Cultured cardiomyocytes treated with <jats:styled-content style=\"fixed-case\">ANG II<\/jats:styled-content> show endogenous interaction between <jats:styled-content style=\"fixed-case\">OLA<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">GSK<\/jats:styled-content>3\u03b2, nuclear accumulation of \u03b2\u2010Catenin and significant increase in cell size and expression of hypertrophic marker genes such as atrial natriuretic factor (<jats:styled-content style=\"fixed-case\">ANF<\/jats:styled-content>;<jats:styled-content style=\"fixed-case\"> NPPA<\/jats:styled-content>) and \u03b2\u2010myosin heavy chain (<jats:styled-content style=\"fixed-case\">MYH<\/jats:styled-content>7). Intriguingly, <jats:styled-content style=\"fixed-case\">OLA<\/jats:styled-content>1 inhibition attenuates the above hypertrophic response in cardiomyocytes. Taken together, our data suggest that <jats:styled-content style=\"fixed-case\">OLA<\/jats:styled-content>1 plays a detrimental role in hypertrophic response via <jats:styled-content style=\"fixed-case\">GSK<\/jats:styled-content>3\u03b2\/\u03b2\u2010catenin signalling. Translation strategies to target <jats:styled-content style=\"fixed-case\">OLA<\/jats:styled-content>1 might potentially limit the underlying molecular derangements leading to left ventricular dysfunction in patients with maladaptive cardiac hypertrophy.<\/jats:p>","DOI":"10.1111\/1440-1681.13101","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T22:10:18Z","timestamp":1557267018000},"page":"743-751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<scp>OBG<\/scp>\u2010like <scp>ATP<\/scp>ase 1 inhibition attenuates angiotensin <scp>II<\/scp>\u2010induced hypertrophic response in human ventricular myocytes via <scp>GSK<\/scp>\u20103beta\/beta\u2010catenin signalling"],"prefix":"10.1111","volume":"46","author":[{"given":"Gayathri","family":"Narasimhan","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Schools of Medicine and Engineering University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Schools of Medicine and Engineering University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hien T","family":"Luong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Schools of Medicine and Engineering University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namakkal Soorapan","family":"Rajasekaran","sequence":"additional","affiliation":[{"name":"Division of Molecular &amp; Cellular Pathology Department of Pathology School of Medicine University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gangjian","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Schools of Medicine and Engineering University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Schools of Medicine and Engineering University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4842-6364","authenticated-orcid":false,"given":"Prasanna","family":"Krishnamurthy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Schools of Medicine and Engineering University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.16"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.59.1.551"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.65.092101.142243"},{"issue":"49","key":"e_1_2_8_5_1","first-page":"865","article-title":"Beta1 integrins modulate beta\u2010adrenergic receptor\u2010stimulated cardiac myocyte apoptosis and myocardial remodeling","volume":"2007","author":"Krishnamurthy P","year":"1979","journal-title":"Hypertension"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007185711745"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00137-16"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep13241"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3MB70501C"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000018952.70505.F1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7224"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B0910009"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.230302"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.5.1371"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00033.2006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-09-0278"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20888"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1934654100"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.13.3797"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5363.596"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.3020"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.40.24735"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02157-05"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.231619298"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103166200"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1440-1681.13101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.13101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1440-1681.13101","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.13101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T22:19:11Z","timestamp":1694297951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.13101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,23]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/1440-1681.13101"],"URL":"https:\/\/doi.org\/10.1111\/1440-1681.13101","archive":["Portico"],"relation":{},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"type":"print","value":"0305-1870"},{"type":"electronic","value":"1440-1681"}],"subject":[],"published":{"date-parts":[[2019,5,23]]},"assertion":[{"value":"2019-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}