{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:23:38Z","timestamp":1777620218204,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to investigate whether the glutathione peroxidase\u20101 gene (GPx\u20101) affects cocaine\u2010induced conditioned place preference (CPP) using a mouse model. Cocaine\u2010induced CPP was accompanied by an increase in the level of \u03c3\u20101 receptor in the nucleus accumbens (NAc). This phenomenon was more pronounced in the GPx\u20101 gene knockout (GPx\u20101 KO) than in wild type (WT) mice. In contrast, the CPP and expression of \u03c3\u20101 receptor were much less pronounced in GPx\u20101\u2010overexpressing transgenic (GPx\u20101 TG) mice than non\u2010transgenic (non\u2010TG) mice. Treatment of the mice with <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"DDBJ\/EMBL\/GenBank\" xlink:href=\"BD1047\">BD1047<\/jats:ext-link>, a \u03c3\u20101 receptor antagonist, significantly attenuated both cocaine\u2010induced CPP and c\u2010Fos\u2010immunoreactivity (c\u2010Fos\u2010IR) in WT and GPx\u20101 KO mice, although the effects were more evident in the latter group. Despite the protective effects of <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"DDBJ\/EMBL\/GenBank\" xlink:href=\"BD1047\">BD1047<\/jats:ext-link> on cocaine\u2010induced CPP and c\u2010Fos in non\u2010TG mice, there were no additional protective effects in cocaine\u2010treated GPx\u20101 TG mice, indicating that the \u03c3\u20101 receptor is a critical target for GPx\u20101\u2010mediated psychoprotective activity. Overall, our results suggest that GPx\u20101 attenuates cocaine\u2010induced CPP via inhibition of \u03c3\u20101 receptor expression.<\/jats:p>","DOI":"10.1111\/1440-1681.13140","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T07:15:22Z","timestamp":1563866122000},"page":"791-797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Glutathione peroxidase\u20101 gene rescues cocaine\u2010induced conditioned place preference in mice by inhibiting <i>\u03c3<\/i>\u20101 receptor expression"],"prefix":"10.1111","volume":"46","author":[{"given":"Duc Toan","family":"Pham","sequence":"first","affiliation":[{"name":"Neuropsychopharmacology and Toxicology Program College of Pharmacy Kangwon National University Chunchon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Hee","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Anatomy College 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