{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:05:33Z","timestamp":1774119933351,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T00:00:00Z","timestamp":1568678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mechanisms of protective action of the neuropeptide galanin and its N\u2010terminal fragments against myocardial ischaemia\/reperfusion (I\/R) injury remain obscure. The aim of this work was to study effects of a novel peptide agonist of galanin receptors [\u03b2Ala14, His15]\u2010galanin (2\u201015) (G1) and the full\u2010length galanin (G2) on energy and antioxidant status of the heart with acute infarction. The peptides were synthesized by the automatic solid phase method using Fmoc technology. Their structure was identified by <jats:sup>1<\/jats:sup>H\u2010<jats:styled-content style=\"fixed-case\">NMR<\/jats:styled-content> spectroscopy and <jats:styled-content style=\"fixed-case\">MALDI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> mass spectrometry. Experiments were performed on anaesthetized open\u2010chest rats subjected to myocardial regional ischaemia and reperfusion. Intravenous (iv) administration of optimal doses of peptides G1 and G2 (1.0 and 0.5\u00a0mg\/kg, respectively, at the onset of reperfusion significantly reduced infarct size (on average by 40% compared with control) and the plasma activity of creatine kinase\u2010<jats:styled-content style=\"fixed-case\">MB<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MB<\/jats:styled-content>) and lactate dehydrogenase (<jats:styled-content style=\"fixed-case\">LDH<\/jats:styled-content>). These effects were associated with augmented preservation of aerobic energy metabolism, increased activity of Cu,Zn superoxide dismutase (Cu,Zn\u2010<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>), catalase (<jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content>) and glutathione peroxidase (<jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content>\u2010Px) and decreased lipid peroxidation in the area at risk (<jats:styled-content style=\"fixed-case\">AAR<\/jats:styled-content>) at the end of reperfusion. Peptide G1 showed more efficient recovery of the majority of metabolic and antioxidant parameters. The results provide evidence that the galaninergic system can be considered a promising target to reduce energy dysregulation and oxidative damage in myocardial I\/R injury.<\/jats:p>","DOI":"10.1111\/1440-1681.13164","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T10:34:40Z","timestamp":1566297280000},"page":"1174-1182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Galanin receptors activation modulates myocardial metabolic and antioxidant responses to ischaemia\/reperfusion stress"],"prefix":"10.1111","volume":"46","author":[{"given":"Irina","family":"Studneva","sequence":"first","affiliation":[{"name":"National Medical Research Center for Cardiology Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa","family":"Serebryakova","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Cardiology Moscow 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