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However, the underlying mechanisms remain unclear. Brain\u2010derived neurotropic factor (BDNF), a neurotrophic factor, plays important regulatory roles in depression by its high\u2010affinity tropomysin\u2010related kinase B (TrkB) receptor. Autophagy also is implicated in modulation of depression. Previous work confirmed the modulatory roles of H<jats:sub>2<\/jats:sub>S in BDNF protein expression and autophagy. Thus, in this study, we explored whether the BDNF\u2010TrkB pathway mediates the antidepressant\u2010like effects of H<jats:sub>2<\/jats:sub>S in diabetic rats and whether this process is achieved via promoting hippocampal autophagy. We demonstrated that H<jats:sub>2<\/jats:sub>S upregulated the expressions of BDNF and p\u2010TrkB proteins in the hippocampus of streptozotocin (STZ)\u2010induced diabetic rats. K252a (an inhibitor of BDNF\u2010TrkB pathway) reversed the antidepressant\u2010like roles of H<jats:sub>2<\/jats:sub>S, as evidenced by the tail suspension, forced swimming, novelty suppressed feeding, and elevated plus\u2010maze tests. Furthermore, K252a abolished H<jats:sub>2<\/jats:sub>S\u2010promoted hippocampal autophagy in diabetic rats, as evidenced by a decrease in the number of autolysosome, downregulation of Beclin\u20101 (a regulator of autophagy in the early stage of the formation of autophagosomal membranes and its level is positively correlated with autophagic activity) expression, and upregulation of P62 (a substrate of autophagic degradation and its level is inversely correlated with autophagic activity) expression, in the hippocampus of rats co\u2010treated with NaHS and STZ. Taken together, these data indicated that the BDNF\u2010TrkB pathway mediates the antidepressant\u2010like roles of H<jats:sub>2<\/jats:sub>S in diabetic rats by enhancing hippocampal autophagy.<\/jats:p>","DOI":"10.1111\/1440-1681.13201","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T11:41:50Z","timestamp":1572349310000},"page":"302-312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["BDNF\u2010TrkB pathway mediates antidepressant\u2010like roles of H<sub>2<\/sub>S in diabetic rats via promoting hippocampal autophagy"],"prefix":"10.1111","volume":"47","author":[{"given":"Hai\u2010Yao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology Affiliated Nanhua Hospital University of South China Hengyang China"},{"name":"Institute of Neuroscience Medical College University of South China Hengyang China"},{"name":"Department of Neurology Hengyang 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