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Four groups of rats were treated as follows; control group, group receiving BPF (1\u00a0\u00b5g\/g b.wt i.p.\/biweekly) for 4\u00a0weeks, group irradiated at 6\u00a0Gy, group receiving BPF post\u2010irradiation for 4\u00a0weeks. Irradiation induced a significant elevation of myocardial parameters: atrial natriuretic peptide (ANP), cardiac troponin I (cTnI), potassium (K<jats:sup>+<\/jats:sup>) and creatine kinase (CK); vascular indices: lactate dehydrogenase (LDH), inducible nitric oxide synthase (iNOS) and endothelin I; oxidative stress indices: malondialdehyde (MDA) associated with a significant depletion of both reduced glutathione (GSH) in the cardiac tissue homogenate and serum ferric reducing antioxidant power (FRAP) depletion and significantly reinforced elevation of Renin Angiotensin Aldosterone System (RAAS) indices: serum angiotensin II (AngII) and aldosterone, and also protein expression of cleaved caspase\u20103 and cyclophilin A. BPF administration altered the biochemical damage of radiation, specifically inhibited AngII formation, aldosterone release and prevented the histopathological and immunohistochemical alterations which were observed in cardiac tissue with significant reduction in mean arterial blood pressure (MAP) caused by irradiation. In conclusion, biochemical assays, histopathological and immunohistochemical findings of the present study demonstrated that exogenous BPF isolated from scorpion venom reduced the cardiomyopathy alterations induced by irradiation <jats:italic>via<\/jats:italic> remodelling of the RAAS pathway.<\/jats:p>","DOI":"10.1111\/1440-1681.13202","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T15:33:27Z","timestamp":1572449607000},"page":"263-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Bradykinin\u2010potentiating factor isolated from <i>Leiurus quinquestriatus<\/i> scorpion venom alleviates cardiomyopathy in irradiated rats <i>via<\/i> remodelling of the RAAS pathway"],"prefix":"10.1111","volume":"47","author":[{"given":"Hesham Farouk","family":"Hasan","sequence":"first","affiliation":[{"name":"Radiation Biology Department National Center for Radiation Research and Technology (NCRRT) Atomic Energy Authority Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha R.","family":"Radwan","sequence":"additional","affiliation":[{"name":"Drug Radiation Research Department National Center for Radiation Research and Technology Atomic Energy Authority Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shereen Mohamed","family":"Galal","sequence":"additional","affiliation":[{"name":"Health Radiation Research Department National Center for Radiation Research and Technology Atomic Energy Authority Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2012.11.022"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2012.02.003"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089160609200213"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2007.06.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/01926230290166724"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2016.07.003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2008.11.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2008.12.008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.1.H275"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01318-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/09553002.2012.715788"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.4.1189"},{"key":"e_1_2_8_14_1","volume-title":"Serological, hematological and biochemical studies on bradykinin potentiating factor isolated from scorpion venom","author":"Salman M","year":"2002"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2011.07.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(92)90784-F"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnci.2015.07.005"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b5349"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2015-0006"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2014.07.007"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000130526.20854.fa"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR13452.1"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2002918"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03085"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-013-1078-5"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201100178"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2018.1465437"},{"issue":"3","key":"e_1_2_8_28_1","first-page":"619","article-title":"Therapeutic response of black tea extract on maintenance pancreas and intestine of gamma\u2010irradiated rats","volume":"5","author":"Lotfi S","year":"2012","journal-title":"J. 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