{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:38:07Z","timestamp":1772159887262,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Peripheral artery disease (PAD) is defined as peripheral blood flow impairment, especially in the legs, caused by atherosclerotic stenosis. The disease decreases quality of life because of intermittent claudication or necrosis of the leg. The hindlimb ischaemia model, in which ischaemia is induced by femoral artery ligation, is often utilized as a PAD model. In the hindlimb ischaemia model, nonmetabolic syndrome animals are mainly used. In this study, we investigated the usefulness of Spontaneously Diabetic Torii\n                    <jats:italic>\n                      Lepr\n                      <jats:sup>fa<\/jats:sup>\n                    <\/jats:italic>\n                    (SDT fatty) rats, a new model for obese type 2 diabetes, as a new PAD animal model. We found that hindlimb blood flow in SDT fatty rats was significantly lower than that in Sprague\u2013Dawley (SD) rats under nonischaemic conditions. Furthermore, SDT fatty rats showed a significantly higher plasma nitrogen oxide level, shorter prothrombin time, and shorter activated partial thromboplastin time than SD rats. In addition, we found that the change in blood flow 7\u00a0days after induction of hindlimb ischaemia and the number of Von Willebrand factor\u2010positive vessels in gastrocnemius muscles were significantly lower in SDT fatty rats than in SD rats. These results suggest that excess production of reactive oxygen species and coagulation activation could be involved in lower blood flow in non\u2010ischaemic rats and that decreased angiogenesis could be involved in the poor recovery of blood flow in SDT fatty rats with hindlimb ischaemia. Taken together, our results suggest that SDT fatty rats might be useful as a new model for PAD with metabolic syndrome.\n                  <\/jats:p>","DOI":"10.1111\/1440-1681.13239","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T11:54:41Z","timestamp":1577102081000},"page":"583-590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of haemodynamics and angiogenic response to ischaemia in the obese type 2 diabetic model Spontaneously Diabetic Torii\n                    <i>\n                      Lepr\n                      <sup>fa<\/sup>\n                    <\/i>\n                    (SDT fatty) rats"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8722-1604","authenticated-orcid":false,"given":"Yasutaka","family":"Murai","sequence":"first","affiliation":[{"name":"Japan Tobacco Inc. Central Pharmaceutical Research Institute Takatsuki Osaka Japan"},{"name":"Faculty of Agriculture Department of Agrobiology Niigata University Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3387-6052","authenticated-orcid":false,"given":"Tomohiko","family":"Sasase","sequence":"additional","affiliation":[{"name":"Japan Tobacco Inc. Central Pharmaceutical Research Institute Takatsuki Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0072-3148","authenticated-orcid":false,"given":"Hironobu","family":"Tadaki","sequence":"additional","affiliation":[{"name":"Japan Tobacco Inc. Central Pharmaceutical Research Institute Takatsuki Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Heitaku","sequence":"additional","affiliation":[{"name":"Japan Tobacco Inc. 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