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Forty male Wistar Albino rats were assigned to four equal groups: the control group, the H<jats:sub>2<\/jats:sub>S control group, the hypertensive group, and the treated group, which received concomitant treatment with sodium hydrosulphide (NaHS) and <jats:sc>l<\/jats:sc>\u2010NAME. Systolic blood pressure (SBP) was measured weekly. Serum levels of nitric oxide (NO), total peroxide, and total antioxidant capacity <jats:bold>(<\/jats:bold>TAC) were measured and the oxidative stress index (OSI) was calculated. Aortic weight and length were measured and the aortic weight\/length ratio determined. Aortic fold expression of interferon\u2010\u03b3 (IFN\u2010\u03b3) and vascular cell adhesion molecule\u20101 (VCAM\u20101) mRNA was measured using qPCR. Aortic media thickness and elastin content were measured morphometrically. <jats:sc>l<\/jats:sc>\u2010NAME administration increased SBP, serum levels of total peroxide and OSI, but reduced serum levels of NO and TAC. Aortic fold expression of IFN\u2010\u03b3 and VCAM\u20101 mRNA, aortic weight, aortic weight\/length ratio, aortic media thickness, and elastin area percentage were increased in the hypertensive group. Concurrent administration of <jats:sc>l<\/jats:sc>\u2010NAME and H<jats:sub>2<\/jats:sub>S attenuated these changes. Thus, H<jats:sub>2<\/jats:sub>S could attenuate the increase in ABP through restoration of the NO level, reduction in the oxidative state, and attenuation of the inflammatory process, thereby reduced vascular remodelling.<\/jats:p>","DOI":"10.1111\/1440-1681.13240","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T16:42:26Z","timestamp":1577119346000},"page":"650-659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of hydrogen sulphide on oxidative stress, inflammatory cytokines, and vascular remodelling in <scp>l<\/scp>\u2010NAME\u2010induced hypertension"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3370-4827","authenticated-orcid":false,"given":"Eman S. 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