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Repeated treatment with AMP resulted in significant increases in proinflammatory cyclooxygenase\u20102 (COX\u20102) and indolemaine\u20102,3\u2010dioxygenase\u20101 (IDO)\u20101 expression in the prefrontal cortex (PFC) of mice. However, AMP treatment did not significantly change IDO\u20102 and 5\u2010lipoxygenase (5\u2010LOX) expression, suggesting that proinflammatory parameters such as COX\u20102 and IDO\u20101 are specific for AMP\u2010induced behaviours. AMP\u2010induced initial expression of COX\u20102 (15\u00a0minutes post\u2010AMP) was earlier than that of IDO\u20101 (1\u00a0hour post\u2010AMP). Mood stabilizer Li and COX\u20102 inhibitor meloxicam significantly attenuated COX\u20102 expression 15\u00a0minutes post\u2010AMP, whereas IDO\u20101 inhibitor 1\u2010methyl\u2010DL\u2010tryptophan (1\u2010MT) did not affect COX\u20102 expression. However, AMP\u2010induced IDO\u20101 expression was significantly attenuated by Li, meloxicam or 1\u2010MT, suggesting that COX\u20102 is an upstream molecule for the induction of IDO\u20101 caused by AMP. Consistently, co\u2010immunoprecipitation between COX\u20102 and IDO\u20101 was observed at 30\u00a0minutes, 1, 3, and 6\u00a0hours after the final AMP treatment. This interaction was also significantly inhibited by Li, meloxicam or 1\u2010MT. Furthermore, AMP\u2010induced hyperlocomotion was significantly attenuated by Li, meloxicam or 1\u2010MT. We report, for the first time, that mood stabilizer Li attenuates AMP\u2010induced mania\u2010like behaviour via attenuation of interaction between COX\u20102 and IDO\u20101, and that the interaction of COX\u20102 and IDO\u20101 may be critical for the therapeutic intervention mediated by mood stabilizer.<\/jats:p>","DOI":"10.1111\/1440-1681.13243","type":"journal-article","created":{"date-parts":[[2019,12,28]],"date-time":"2019-12-28T05:40:50Z","timestamp":1577511650000},"page":"790-797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lithium attenuates d\u2010amphetamine\u2010induced hyperlocomotor activity in mice via inhibition of interaction between cyclooxygenase\u20102 and indoleamine\u20102,3\u2010dioxygenase"],"prefix":"10.1111","volume":"47","author":[{"given":"Dieu\u2010Hien","family":"Phan","sequence":"first","affiliation":[{"name":"Neuropsychopharmacology and Toxicology Program BK21 PLUS Project 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