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The non\u2010classical RAS involves the conversion of Ang II via ACE2 into the vasodilator Ang (1\u20107) to counterbalance the effects of Ang II. Furthermore, ACE2 converts AngA into another vasodilator named alamandine. The over activation of the classical RAS (increased vasoconstriction) and depletion of the non\u2010classical RAS (decreased vasodilation) results in vascular dysfunction. Vascular dysfunction is the leading cause of atherosclerosis and cardiovascular disease (CVD). Additionally, local RAS is expressed in various tissues and regulates cellular functions. RAS dysregulation is involved in other several diseases such as inflammation, renal dysfunction and even cancer growth. An approach in restoring vascular dysfunction and other pathological diseases is to either increase the activity of ACE2 or reduce the effect of the classical RAS by counterbalancing Ang II effects. The antitrypanosomal agent, diminazene aceturate (DIZE), is one approach in activating ACE2. DIZE has been shown to exert beneficial effects in CVD experimental models of hypertension, myocardial infarction, type 1 diabetes and atherosclerosis. Thus, this review focuses on DIZE and its effect in several tissues such as blood vessels, cardiac, renal, immune and cancer cells.<\/jats:p>","DOI":"10.1111\/1440-1681.13251","type":"journal-article","created":{"date-parts":[[2020,1,4]],"date-time":"2020-01-04T13:14:51Z","timestamp":1578143691000},"page":"751-758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["The potential actions of angiotensin\u2010converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases"],"prefix":"10.1111","volume":"47","author":[{"given":"Tawar","family":"Qaradakhi","sequence":"first","affiliation":[{"name":"Institute for Health and Sport Victoria University Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Kate","family":"Gadanec","sequence":"additional","affiliation":[{"name":"Institute for Health and Sport Victoria University Melbourne 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