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Different advantageous perinatal factors proved to have beneficial long\u2010lasting effects against an abnormal genetic background. Taurine is a ubiquitous sulphur\u2010containing amino acid present in foods such as seafood. The antihypertensive effects of taurine have been reported in experimental studies and in human hypertension. We aimed to investigate the effects of perinatal treatment with taurine in spontaneously hypertensive rats (SHR), a known model of genetic hypertension. Female SHR were administered with taurine (3\u00a0g\/L) during gestation and lactation (SHR\u2010TAU). Untreated SHR and Wistar\u2010Kyoto rats (WKY) were used as controls. Long\u2010lasting effects in offspring were investigated. Addition of taurine to the mother's drinking water reduced blood pressure in adult offspring. No differences were observed in cardiac hypertrophy. Findings on morphometric evaluations suggest that perinatal treatment with taurine would be partially effective in improving structural alterations of the aorta. Modifications in gene expression of Bcl\u20102 family members and upregulation of endothelial nitric oxide synthase in the aorta of 22\u2010week\u2010old male offspring were found. No differences were observed on relative telomere length in different cardiovascular tissues between SHR and SHR\u2010TAU. Altogether results suggest that taurine programming, albeit sex specific, is associated with gene expression changes which ultimately may lead to improvement of aortic remodelling and enhanced endothelial function because of augmented nitric oxide (NO) production.<\/jats:p>","DOI":"10.1111\/1440-1681.13260","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T09:31:39Z","timestamp":1579512699000},"page":"780-789","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Perinatal taurine exerts a hypotensive effect in male spontaneously hypertensive rats and down\u2010regulates endothelial oxide nitric synthase in the aortic arch"],"prefix":"10.1111","volume":"47","author":[{"given":"Melisa F.","family":"Mensegue","sequence":"first","affiliation":[{"name":"Institute of Medical Research A. Lanari University of Buenos Aires Ciudad Aut\u00f3noma de Buenos Aires Argentina"},{"name":"Department of Molecular Genetics and Biology of Complex Diseases Institute of Medical Research (IDIM) National Scientific and Technical Research Council (CONICET) Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana L.","family":"Burgue\u00f1o","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) Pontificia Universidad Cat\u00f3lica Argentina Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1194-8433","authenticated-orcid":false,"given":"Mariana L.","family":"Tellechea","sequence":"additional","affiliation":[{"name":"Institute of Medical Research A. 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