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Broth microdilution assay was used to determine minimum inhibitory concentrations (MICs) of cinnamaldehyde (CIN), eugenol (EG) and traditional antibiotics against ESBL\u2010QR <jats:italic>Enterobactericeae<\/jats:italic>. Sub\u2010acute oral toxicity study (14\u00a0days) was carried out in Swiss albino mice to evaluate any toxicological and behavioural effect viz novelty suppressed feeding (NSF), novel object recognition (NOR), tail suspension test (TST) and social interaction test of cinnamaldehyde and eugenol. Cinnamaldehyde and eugenol demonstrated mode\u2010MIC of 7.28 and 7.34\u00a0\u03bcg\/mL among maximum numbers of <jats:italic>Escherichia\u00a0coli<\/jats:italic> (32.1%) and 0.91 and 3.67\u00a0\u03bcg\/mL among maximum numbers of <jats:italic>Klebsiella \u00a0pneumoniae<\/jats:italic> (24.2%) isolates, respectively. For haematological and toxicological analyses, after 14\u00a0days of oral administration of cinnamaldehyde (0.91\u201310\u00a0mg\/kg) and eugenol (7.34\u201370\u00a0mg\/kg), blood was collected from the murine model, while histological examinations were performed on liver and kidney. There was no alteration in food and water intake among treated animals. Toxicological and behavioural studies displayed good safety profiles of cinnamaldehyde and eugenol. The results indicated potential antibacterial efficacy of cinnamaldehyde and eugenol against pathogenic ESBL\u2010QR Enterobacteriaceae, without any significant toxicological and behavioural effects.<\/jats:p>","DOI":"10.1111\/1440-1681.13276","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T15:31:23Z","timestamp":1581003083000},"page":"977-988","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Sub\u2010acute toxicological and behavioural effects of two candidate therapeutics, cinnamaldehyde and eugenol, for treatment of ESBL producing\u2010quinolone resistant pathogenic <i>Enterobacteriaceae<\/i>"],"prefix":"10.1111","volume":"47","author":[{"given":"Lena","family":"Dhara","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Medical Biotechnology Calcutta School of Tropical Medicine Kolkata West Bengal 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