{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T05:20:32Z","timestamp":1776835232091,"version":"3.51.2"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,8]],"date-time":"2020-03-08T00:00:00Z","timestamp":1583625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["1808085QH245"],"award-info":[{"award-number":["1808085QH245"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Imbalance of T helper 17 (Th17)\/regulatory T (Treg) cells is involved in the pathogenesis of myasthenia gravis with thymoma (MG\u2010T). Long non\u2010coding RNAs (lncRNAs) are implicated in the regulation of Th17\/Treg balance. This study was designed to explore the role of XLOC_003810, a novel lncRNA, in regulating the Th17\/Treg balance in MG\u2010T. The thymic CD4<jats:sup>+<\/jats:sup> T cells were isolated from control subjects and MG\u2010T patients. The Th17\/Treg balance was evaluated by determining proportions of Th17 and Treg cells and expression of Th17\u2010 and Treg\u2010 associated molecules. Lentivirus\u2010mediated silencing and overexpression of XLOC_003810 in CD4<jats:sup>+<\/jats:sup> T cells were performed. The results showed that XLOC_003810 expression was higher in MG\u2010T thymic CD4<jats:sup>+<\/jats:sup> T cells than that in the control group. Furthermore, the ratio of Th17\/Treg cells, proportion of Th17 cells and levels of Th17\u2010associated molecules were significantly increased, whereas the proportion of Treg cells and levels of Treg\u2010associated molecules were decreased in MG\u2010T thymic CD4<jats:sup>+<\/jats:sup> T cells. Importantly, the Th17\/Treg imbalance in MG\u2010T thymic CD4<jats:sup>+<\/jats:sup> T cells was aggravated by XLOC_003810 overexpression, whereas it was attenuated by XLOC_003810 silencing. Collectively, XLOC_003810 modulates thymic Th17\/Treg balance in MG\u2010T patients, providing the scientific basis for the clinical targeted therapy of MG\u2010T.<\/jats:p>","DOI":"10.1111\/1440-1681.13280","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T06:10:35Z","timestamp":1581487835000},"page":"989-996","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["LncRNA XLOC_003810 modulates thymic Th17\/Treg balance in myasthenia gravis with thymoma"],"prefix":"10.1111","volume":"47","author":[{"given":"Li","family":"Niu","sequence":"first","affiliation":[{"name":"Department of Radiotherapy The First Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy The First Affiliated Hospital of Anhui Medical University Hefei 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