{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:22:46Z","timestamp":1790230966166,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["18ZXDBSY00030"],"award-info":[{"award-number":["18ZXDBSY00030"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871184"],"award-info":[{"award-number":["31871184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830026"],"award-info":[{"award-number":["81830026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Tumour necrosis factor ligand related molecule 1 A (TL1A), a member of tumour necrosis factor superfamily, has been identified as a crucial regulator for vascular homeostasis and inflammation. However, the function of TL1A in diabetic retinopathy (DR) is largely unknown. This study aims to examine levels of TL1A in serum and intraocular fluid in patients with proliferative diabetic retinopathy (PDR), and to explore the correlation of intraocular TL1A with the prognosis of PDR progression after primary vitrectomy. Seventy\u2010five patients (75 eyes) with PDR who underwent pars plana vitrectomy (PPV) and 19 patients (19 eyes) who received vitrectomy for idiopathic macular holes (IMH) as non\u2010diabetic control group were enrolled in this prospective study. Serum, aqueous and vitreous fluid samples were collected during cataract and PPV surgery. Protein expressions of TL1A as well as other angiogenic and inflammatory cytokines in serum and intraocular fluid were measured. Correlations of intraocular TL1A concentrations with inflammatory cytokines were analyzed. We found both aqueous and vitreous TL1A levels were significantly higher in the PDR group than in control group (\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>aqueous<\/jats:sub>\n                    \u00a0=\u00a00.026;\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>vitreous<\/jats:sub>\n                    &lt;0.001). Angiogenic and inflammatory cytokines such as VEGF, IL\u20106, IL\u20108, MCP\u20101, MIP\u20101\u03b1, and MIP\u20101\u03b2 were significantly higher in intraocular fluid in PDR group than in controls, which MCP\u20101 and MIP\u20101\u03b1 showed positive correlation with intraocular TL1A levels. There is no significant difference in the levels of serum TL1A as well as other inflammatory cytokines between PDR patients and controls. Intraocular levels of TL1A were significantly lower in PDR progression group than in the stable group (\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>aqueous<\/jats:sub>\n                    &lt;0.001;\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>vitreous<\/jats:sub>\n                    &lt;0.001). Multivariate logistic regression analyses revealed that lower levels of intraocular TL1A was an important risk factor for predicting PDR progression after primary PPV (OR\n                    <jats:sub>aqueous<\/jats:sub>\n                    \u00a0=\u00a00.717,\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>aqueous<\/jats:sub>\n                    \u00a0=\u00a00.001; OR\n                    <jats:sub>vitreous<\/jats:sub>\n                    \u00a0=\u00a00.684;\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>vitreous<\/jats:sub>\n                    \u00a0=\u00a00.002). In conclusion, TL1A and multiple inflammatory cytokines were highly enriched in the intraocular fluid of PDR patients compared with the controls. Lower levels of intraocular TL1A were associated with development of PDR complications after primary PPV and might be used as prognostic factor in predicting the vitrectomy outcome in PDR patients.\n                  <\/jats:p>","DOI":"10.1111\/1440-1681.13284","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:25:15Z","timestamp":1581899115000},"page":"966-976","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intraocular tumour necrosis factor ligand related molecule 1 A links disease progression of proliferative diabetic retinopathy after primary vitrectomy"],"prefix":"10.1111","volume":"47","author":[{"given":"Tian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruotian","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Emory University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual Science Tianjin Eye Institute Clinical College of Ophthalmology Tianjin Medical University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Tianjin Key Laboratory of Inflammation Biology School of Basic Medical Sciences Tianjin Medical University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Tianjin Key Laboratory of Inflammation Biology School of Basic Medical Sciences Tianjin Medical University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Mississippi Medical Center Jackson MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Brant","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences Federal University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology &amp; Visual Sciences Montefiore Medical Center Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9115-490X","authenticated-orcid":false,"given":"Hua","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1909"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1047"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.4.552"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2199-0"},{"issue":"10","key":"e_1_2_7_6_1","first-page":"629452","article-title":"Therapeutic interventions against inflammatory and angiogenic mediators in proliferative diabetic retinopathy","volume":"2012","author":"Gologorsky D","year":"2012","journal-title":"Mediators 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