{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:38:17Z","timestamp":1772159897249,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This research aims to improve anaesthesia services given to preterm infants by the use of dexamethasone and aminophylline administrated under sevoflurane, and to analyze its effect on the cell\u2010mediated immunity (CD4+CD25+Foxp3+(T\u2010reg) and CD4+CD25highFoxp3+CD127low). We have examined 74 premature babies with retinopathy of prematurity (ROP) at the 3\u20135 stages during the 25\u201332 week gestation period (1\u20136\u00a0months after birth). Both immunomodulators had no significant effect on clinical parameters after one dose (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&gt;\u00a0.05). Aminophylline (2.4% solution, 0.1\u00a0mL\/kg or 0.132\u00a0mL per infant on average) and dexamethasone (0.4% solution, 0.1\u00a0mg\/kg or 0.132\u00a0mL per infant on average) were intravenously injected 15\u00a0minutes before the end of the surgery. Required anaesthesia depth was maintained with inhalation anaesthetic (1.5\u20132.0 IAC), and the minimum fresh gas flow was not less than 2\u00a0L. Blood samples were taken from the vein (anaesthesia induction stage) into the tubes containing EDTA (the anticoagulant), stored at 20\u201325\u00b0C, and then, processed and stained within 24\u00a0hours after sampling. Both immunomodulators had no significant effect on clinical parameters after one dose (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&gt;\u00a0.05). Short\u2010term shift in regulatory T\u2010cell level affected by dexamethasone has a negative effect combined with further withdrawal effect that this hormonal drug has. Aminophylline has such clinical effects as improving pulmonary ventilation, decrease in apnoea frequency, and improving blood gas indices. Aminophylline has less expressed but more prolonged positive effect during the day when used for several days. It may lead to a persistent positive effect with progressive treatment outcomes.\n                  <\/jats:p>","DOI":"10.1111\/1440-1681.13308","type":"journal-article","created":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T09:45:30Z","timestamp":1584783930000},"page":"1368-1373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immunological outcomes in infants with ROP after dexamethasone and aminophylline"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6752-201X","authenticated-orcid":false,"given":"Larisa","family":"Balashova","sequence":"first","affiliation":[{"name":"Library of Children's Ophthalmology Pirogov Russian National Research Medical University (PRNIMU) Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Bykovskaya","sequence":"additional","affiliation":[{"name":"Departament of Cell\u2019s Technology and Regenerative Medicine Pirogov Russian National Research Medical University (PRNIMU) Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludmila","family":"Korobova","sequence":"additional","affiliation":[{"name":"Departament of Anesthesiology Pirogov Russian National Research Medical University (PRNIMU) Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulia","family":"Kuznetsova","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Pirogov Russian National Research Medical University (PRNIMU) Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Kantardgy","sequence":"additional","affiliation":[{"name":"Library of Children's Ophthalmology Pirogov Russian National Research Medical University (PRNIMU) Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Mukhin","sequence":"additional","affiliation":[{"name":"Departament of 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