{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:39:01Z","timestamp":1772159941937,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T00:00:00Z","timestamp":1590364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hypertension and coronary events are becoming more prevalent in aging societies, and myocardial infarction usually occurs in calcium channel blocker (CCB)\u2010treated hypertensive patients. We herein compared the effects of cilnidipine, an L\/N\u2010type CCB and amlodipine, an L\u2010type CCB, on post\u2010infarct left ventricular (LV) remodelling in spontaneously hypertensive rats (SHRs). Male SHRs were subjected to 30\u00a0minutes of left coronary artery occlusion followed by reperfusion (MI group). The administration of cilnidipine (10\u00a0mg\/kg\/d; MI\u00a0+\u00a0Cil group) or amlodipine (10\u00a0mg\/kg\/d; MI\u00a0+\u00a0Aml group) was initiated one week before surgery and continued for five weeks. Both CCBs decreased blood pressure. Four weeks after surgery, cilnidipine, but not amlodipine, attenuated LV dilatation, fractional shortening impairments, end\u2010diastolic pressure elevations, and tau elongation. In the non\u2010infarct region, myocyte hypertrophy and brain natriuretic peptide (BNP) mRNA levels were similarly attenuated by both CCBs. On the other hand, interstitial fibrosis, the mRNA expression of collagen type III and transforming growth factor (TGF) \u03b2 and immunohistological TGF \u03b2 protein expression in the non\u2010infarct region were reduced more in the MI\u00a0+\u00a0Cil group than in the MI\u00a0+\u00a0Aml group. Additionally, elevated angiotensin\u2010converting enzyme activity and interstitial noradrenaline concentrations in the non\u2010infarct region were reduced by cilnidipine. These results suggest that cilnidipine reduced cardiac noradrenaline concentrations and inhibited the renin\u2013angiotensin system, which attenuated post\u2010infarct remodelling more than amlodipine in hypertensive rats.<\/jats:p>","DOI":"10.1111\/1440-1681.13329","type":"journal-article","created":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T04:36:45Z","timestamp":1587616605000},"page":"1545-1553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of effects of L\/N\u2010type and L\u2010type calcium channel blockers on post\u2010infarct cardiac remodelling in spontaneously hypertensive rats"],"prefix":"10.1111","volume":"47","author":[{"given":"Nessa","family":"Naseratun","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Division of Pathological Science Kyoto Pharmaceutical University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7597-8017","authenticated-orcid":false,"given":"Miyuki","family":"Kobara","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Division of Pathological Science Kyoto Pharmaceutical University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Division of Pathological Science Kyoto Pharmaceutical University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroe","family":"Toba","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Division of Pathological Science Kyoto Pharmaceutical University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Nakata","sequence":"additional","affiliation":[{"name":"Department of 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