{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:39:02Z","timestamp":1772159942121,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We sought to determine whether adjusting the indices used to assess beta cell function by anthropometric markers of obesity improves their clinical value in a diabetic population. We conducted a cross\u2010sectional survey of 3732 diabetic patients who underwent a 100\u00a0g carbohydrate meal test. Insulin secretion was estimated using HOMA\u2010B of steady state as well as \u25b3\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>0\u201030<\/jats:sub>\n                    \/\u25b3\n                    <jats:italic>G<\/jats:italic>\n                    <jats:sub>0\u201030<\/jats:sub>\n                    , \u25b3AUC\n                    <jats:sub>c30\u2010120<\/jats:sub>\n                    \/\u25b3AUC\n                    <jats:sub>G30\u2010120<\/jats:sub>\n                    and CPI\n                    <jats:sub>n<\/jats:sub>\n                    for dynamic state. Body weight index, waist circumference, waist\u2010hip ratio and body surface area were recorded. The final analysis included 2873 T2DM patients. Correlation analyses showed that there was a poor correlation between diabetic duration and CPI\n                    <jats:sub>30<\/jats:sub>\n                    (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a0\u2212.040,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.05), and there were no remarkable changes in the correlation coefficient after CPI\n                    <jats:sub>30<\/jats:sub>\n                    was divided by BMI, WC, WHR, or body surface area, respectively. The same was found for the correlation between HbA1c and CPI\n                    <jats:sub>120<\/jats:sub>\n                    with these measures. The main determinants of diabetic duration were age (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u00a0=\u00a00.388,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001), log HOMA\u2010IR (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u00a0=\u00a0\u22120.328,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001), CPI\n                    <jats:sub>30<\/jats:sub>\n                    (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u00a0=\u00a0\u22120.045,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.011). There were no remarkable changes in \u03b2 weights between diabetic duration and CPI\n                    <jats:sub>30<\/jats:sub>\n                    when it was corrected with anthropometric markers in the multiple stepwise linear regression analyses. The same was found between HbA\n                    <jats:sub>1c<\/jats:sub>\n                    and CPI\n                    <jats:sub>120<\/jats:sub>\n                    . CPI\n                    <jats:sub>30<\/jats:sub>\n                    and CPI\n                    <jats:sub>120<\/jats:sub>\n                    are more practical indexes. Correcting the indices used to estimate the beta cell function by anthropometric markers of obesity may not improve their correlations with diabetic duration or HbA\n                    <jats:sub>1c<\/jats:sub>\n                    in a diabetic population.\n                  <\/jats:p>","DOI":"10.1111\/1440-1681.13337","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T09:00:09Z","timestamp":1589619609000},"page":"1509-1516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Estimates of beta cell function adjusted by anthropometric markers in patients with T2DM"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1002-3009","authenticated-orcid":false,"given":"Mingchen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Endocrinology First Affiliated Hospital of Xinjiang Medical University Urumqi China"},{"name":"Postdoctoral Research Station of Public Health School of Public Health Xinjiang Medical University Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinxia","family":"Su","sequence":"additional","affiliation":[{"name":"Health Management Institute First Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology First Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology First Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Yao","sequence":"additional","affiliation":[{"name":"Postdoctoral Research Station of Public Health School of Public Health Xinjiang Medical University Urumqi China"},{"name":"The Key Laboratory of Xinjiang Metabolic Disease Clinical Medical Research Institute First Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.168118"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.44.11.1249"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07037-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1392"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066224"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399810666140214093600"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.19.3.278"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.6.1487"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1478"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2015.10.024"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.333.7570.695"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1514009"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13143"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2014.04.006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21256"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70062-7"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20604"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2008.11.017"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2013.033"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.05.014"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2017.194"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-Sppc01"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15239"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S"}],"container-title":["Clinical 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