{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:40:22Z","timestamp":1787013622234,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T00:00:00Z","timestamp":1592006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study evaluated if the nephroprotective effect of Salidroside in type 1 diabetes mellitus (T1DM) involves modulation of Wnt\/\u03b2\u2010catenin signalling pathways. Control or Streptozotocin (STZ, 50\u00a0mg\/kg, iv)\u2010induced T1DM adult male Wister rats were treated with the vehicle and Salidroside (100\u00a0mg\/kg, orally) for 8\u00a0weeks daily. As compared to T1DM\u2010induced rats, Salidroside improved kidney structure, reduced urinary protein and albumin level, increased creatinine clearance, and suppressed renal fibrosis. It also decreased mRNA and protein levels of Wnt1, Wnt3, and TGF\u2010\u03b21, phosphorylation of Smad\u20103, total and nuclear levels of \u03b2\u2010catenin, and levels and activities of cleaved caspase\u20103. Concomitantly, Salidroside significantly increased the levels of p\u2010\u03b2\u2010catenin (Ser\n                    <jats:sup>33\/37<\/jats:sup>\n                    \/Thr\n                    <jats:sup>41<\/jats:sup>\n                    ) and suppressed protein levels of Axin\u20102, fibronectin, and, mRNA and protein levels of collagen IIIa, the main targets of \u03b2\u2010catenin. In both control and T1DM rats, Salidroside significantly lowered fasting glucose levels and reduced renal levels of reactive oxygen species (ROS) p\u2010and GS3K\u03b2 (Ser9) but significantly increased levels of SOD and GSH. In conclusion, Salidroside protected the kidney of rats against T1DM\u2010induced injury and fibrosis by activating GS3K\u03b2\u2010induced inhibition of Wnt1\/Wnt3a \u03b2\u2010catenin. This was associated with hypoglycaemic and antioxidant effects.\n                  <\/jats:p>","DOI":"10.1111\/1440-1681.13355","type":"journal-article","created":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T05:50:24Z","timestamp":1590817824000},"page":"1692-1704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Salidroside protects against diabetes mellitus\u2010induced kidney injury and renal fibrosis by attenuating TGF\u2010\u03b21 and Wnt1\/3a\/\u03b2\u2010catenin signalling"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1800-7238","authenticated-orcid":false,"given":"Ali A.","family":"Shati","sequence":"first","affiliation":[{"name":"Department of Biology College of Science King Khalid University (KKU) Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad 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