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We evaluated the antihypertensive effect of the CARV free and encapsulation of CARV in \u03b2\u2010cyclodextrin (CARV\/\u03b2\u2010CD), and whether CARV\/\u03b2\u2010CD is able to improve the antihypertensive effects of CARV free in spontaneously hypertensive rats (SHR). The rats were randomly divided into four groups, each treated daily for 21\u00a0days and the mean arterial pressure and heart rate was measured every 5\u00a0days: group 1, Wistar\u2010vehicle solution; group 2, SHR\u2010vehicle; group 3, SHR\u2010CARV 50\u00a0mg\/kg\/d; and group 4, CARV\/\u03b2\u2010CD 50\u00a0mg\/kg\/d. After 21\u00a0days of treatment, the mesenteric artery from treated animals was tested for phenylephrine (Phe) and sodium nitroprusside (SNP) sensitivity. In addition, administration of CARV\/\u03b2\u2010CD induced important antihypertensive activity when compared with the uncomplexed form, reducing the progression of arterial hypertension in SHR. Moreover, pharmacological potency to Phe in the SHR\u2010CARV and CARV\/\u03b2\u2010CD groups was increased, approaching values expressed in the Wistar\u2010vehicle. Furthermore, CARV\/\u03b2\u2010CD reduced the production of the pro\u2010inflammatory mediator, IL\u20101\u03b2, and increased anti\u2010inflammatory cytokine, IL\u201010. Together, these results produced evidence that the encapsulation of CARV in \u03b2\u2010CD can improve cardiovascular activity, showing potential anti\u2010inflammatory and antihypertensive effects.<\/jats:p>","DOI":"10.1111\/1440-1681.13364","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T11:26:39Z","timestamp":1592825199000},"page":"1798-1807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Antihypertensive effect of carvacrol is improved after incorporation in \u03b2\u2010cyclodextrin as a drug delivery system"],"prefix":"10.1111","volume":"47","author":[{"given":"Liliane","family":"Barreto da Silva","sequence":"first","affiliation":[{"name":"Laboratory of Cardiovascular Physiology and Pharmacology Federal University of Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel Barbosa","family":"Camargo","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Physiology and Pharmacology Federal University of Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raiana dos Anjos","family":"Moraes","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Physiology and Pharmacology Federal University of Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla Fiama","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Physiology and Pharmacology Federal University of Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson de Melo","family":"Jesus","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Physiology and Pharmacology Federal University of Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afr\u00e2nio","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Federal University of Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane Flora","family":"Villarreal","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Federal University of Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucindo Jos\u00e9","family":"Quintans\u2010J\u00fanior","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences Federal University of Sergipe Aracaju Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8746-6449","authenticated-orcid":false,"given":"Dar\u00edzy Fl\u00e1via","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Physiology and Pharmacology Federal University of Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018912"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31919-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1518-8787.2017051000006"},{"key":"e_1_2_9_5_1","volume-title":"Hearts: Technical Package for Cardiovascular Disease Management in Primary Health Care","author":"World Health Organization","year":"2016"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2011.00758.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161211798157667"},{"issue":"2","key":"e_1_2_9_8_1","first-page":"312","article-title":"Review of new hypertension guidelines","volume":"19","author":"Zhang PY","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303603"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2018-313599"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.79097"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.09.106"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161208786404227"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2004.05.002"},{"key":"e_1_2_9_15_1","unstructured":"EAFUS: a Food Additive Database. 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