{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:29:53Z","timestamp":1793474993000,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88882.315862\/2019\u201001"],"award-info":[{"award-number":["88882.315862\/2019\u201001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["445325\/2014\u20103"],"award-info":[{"award-number":["445325\/2014\u20103"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diminazene aceturate (DIZE) has been described as an angiotensin\u2010converting enzyme 2 (ACE2) activator. We aimed to investigate DIZE effects on blood pressure (BP) of spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats. BP was recorded in awake and unrestrained rats 24\u00a0hours after femoral artery catheterization. DIZE (15\u00a0mg\/kg, s.c.) produced a fast BP decrease only in SHR (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.01). Pre\u2010treatment with L\u2010NAME (10\u00a0mg\/kg, iv) did not change the hypotensive effect on systolic BP whereas mitigated the DIZE effect on diastolic BP (\u2206 Emax: \u221231\u00a0\u00b1\u00a05 DIZE vs \u221215\u00a0\u00b1\u00a01\u00a0mm\u00a0Hg DIZE\u00a0+\u00a0L\u2010NAME,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.05). BP changes after DIZE remained unchanged after the treatment of rats with A\u2010779 (50\u00a0ug\/kg, iv), a Mas receptor blocker. Vasodilatation curves to DIZE (10\n                    <jats:sup>\u20109<\/jats:sup>\n                    to 10\n                    <jats:sup>\u20104<\/jats:sup>\n                    \u00a0mol\/L) in mesenteric arteries confirmed the NO\u2010mediation on DIZE effects in SHR, as L\u2010NAME (300\u00a0\u03bcmol\/L) reduced the vascular sensitivity (\u2206EC50: \u22125.12\u00a0\u00b1\u00a00.09 CONTROL vs \u22124.66\u00a0\u00b1\u00a00.08 L\u2010NAME,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.05) and the magnitude of DIZE effect (area under the curve (AUC), 357.5\u00a0\u00b1\u00a08.2 DIZE vs 424.7\u00a0\u00b1\u00a011.6 L\u2010NAME;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001), whereas A\u2010779 (1\u00a0\u03bcmol\/L) enhanced DIZE response (AUC, 357.5\u00a0\u00b1\u00a08.2 DIZE vs 309.8\u00a0\u00b1\u00a014.7 A\u2010779,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.05). Our findings indicate that DIZE acutely reduces the BP in SHR possibly by a mechanism other than Mas receptor activation. This effect seems to be mediated, at least partially, by NO.\n                  <\/jats:p>","DOI":"10.1111\/1440-1681.13368","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T17:46:40Z","timestamp":1593539200000},"page":"1723-1730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Acute hypotensive effect of diminazene aceturate in spontaneously hypertensive rats: role of NO and Mas receptor"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2341-1596","authenticated-orcid":false,"given":"Carmem Lu\u00edza","family":"Sart\u00f3rio","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences Federal University of Espirito Santo (UFES) Espirito Santo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0234-3838","authenticated-orcid":false,"given":"Enildo 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