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Previous studies reported the pharmacological benefits of ALA such as glycaemic control, improved insulin sensitivity and alleviation of diabetic complications such as neuropathy and cardiovascular diseases. Dry eye disease and retinopathy are prevalent in diabetic patients. Experimental studies demonstrated the beneficial effects of ALA in dry eye and diabetic retinopathy. ALA can prevent the dry eye by down regulating the expression of matrix metalloproteinase\u20109 in the corneal epithelial cells and activating the antioxidant status of the ocular surface. Furthermore, its direct antioxidant effect can also prevent oxidative stress\u2010induced corneal surface erosion and lachrymal gland damage. ALA prevents diabetic retinopathy through inhibition of\n                    <jats:italic>O<\/jats:italic>\n                    \u2010linked \u03b2\u2010N\u2010acetylglucosamine transferase and nuclear factor\u2010kappa B activity and alleviation of oxidative stress. It can activate the nuclear factor erythroid\u20102\u2010related factor 2 and AMP\u2010activated protein kinase in retinal ganglion cells. Clinical trials conducted in pre\u2010retinopathic diabetic patients showed ALA with genistein and vitamins could protect the retinal cells and decline the inflammatory effect in diabetic patients. However, studies are scant to explore its beneficial effects in dry eye disease and diabetic retinopathy. Therefore, this review article discusses an update on the role of ALA in dry eye disease and diabetic retinopathy, two ocular diseases prevalent in diabetic patients.\n                  <\/jats:p>","DOI":"10.1111\/1440-1681.13373","type":"journal-article","created":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T05:06:00Z","timestamp":1593839160000},"page":"1883-1890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Alpha\u2010lipoic acid: A possible pharmacological agent for treating dry eye disease and retinopathy in diabetes"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9915-846X","authenticated-orcid":false,"given":"Thekkuttuparambil A.","family":"Ajith","sequence":"first","affiliation":[{"name":"Department of Biochemistry Amala Institute of Medical Sciences Thrissur 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