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Blood pressure and some parameters of cardiovascular remodelling were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Systolic blood pressure (SBP) was higher in 2K\u20101C (209\u00a0\u00b1\u00a03\u00a0mm\u00a0Hg,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05) than in 2K (113\u00a0\u00b1\u00a01\u00a0mm\u00a0Hg) rats. There was an additional effect in 2K\u20101C treated with LOS\u00a0+\u00a0ENA (153\u00a0\u00b1\u00a09\u00a0mm\u00a0Hg) on lowering SBP when compared to LOS (184\u00a0\u00b1\u00a012\u00a0mm\u00a0Hg) or ENA (177\u00a0\u00b1\u00a09\u00a0mm\u00a0Hg). None of the treatments had effect on SBP in 2K rats. In 2K\u20101C, cardiomyocyte hypertrophy was reduced by all treatments, although the cardiac hypertrophy indexes remained unchanged. 2K\u20101C aortas presented medial thickening that was partially reduced by the treatments. Intimal hyperplasia observed in 2K\u20101C (15.56\u00a0\u00b1\u00a00.89\u00a0\u00b5m vs 8.24\u00a0\u00b1\u00a00.80\u00a0\u00b5m) was reversed by ENA (9.52\u00a0\u00b1\u00a00.45\u00a0\u00b5m) or LOS\u00a0+\u00a0ENA (8.17\u00a0\u00b1\u00a00.53\u00a0\u00b5m). Collagen deposition was increased in 2K\u20101C hearts (1.77\u00a0\u00b1\u00a00.16 vs 1.28\u00a0\u00b1\u00a00.09) and aortas (8.1\u00a0\u00b1\u00a00.6 vs 5.2\u00a0\u00b1\u00a00.2). Treatment with LOS reduced (1.12\u00a0\u00b1\u00a00.14%) and ENA (0.81\u00a0\u00b1\u00a00.11%) or LOS\u00a0+\u00a0ENA (0.86\u00a0\u00b1\u00a00.11%) additionally diminished collagen only in 2K\u20101C hearts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Submaximal doses of ACEi and\/or ARB have inhibitory actions on cardiac remodelling and vascular hypertrophy not entirely dependent on their effects on blood pressure normalization in renovascular hypertensive rats. Combined therapy produced additional reduction in blood pressure than monotherapy despite a similar inhibition on cardiovascular remodelling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1440-1681.13384","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T17:12:39Z","timestamp":1595265159000},"page":"1965-1977","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Reversion of cardiovascular remodelling in renovascular hypertensive 2K\u20101C rats by renin\u2013angiotensin system inhibitors"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9580-3361","authenticated-orcid":false,"given":"Jos\u00e9 Wilson do Nascimento","family":"Corr\u00eaa","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences Biological Sciences Institute Federal University of Amazonas (UFAM) Manaus Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4321-0879","authenticated-orcid":false,"given":"Cibele Maria","family":"Prado","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine of Ribeir\u00e3o Preto University of S\u00e3o Paulo (USP) Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elena","family":"Riul","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine of Ribeir\u00e3o Preto University of S\u00e3o Paulo (USP) Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9728-8033","authenticated-orcid":false,"given":"Alice Valen\u00e7a","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Nucleus of Public Health Academic Center of Vit\u00f3ria (CAV) Federal University of Pernambuco (UFPE) Vit\u00f3ria de Santo Ant\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Antonio","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine of Ribeir\u00e3o Preto University of S\u00e3o Paulo (USP) Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5788-6709","authenticated-orcid":false,"given":"Lusiane Maria","family":"Bendhack","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo (USP) Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199100182-00006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-008-0050-x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2009.05.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(02)03006-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(91)90207-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.36.1.89"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.103440"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199406242-00003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2008.07788.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90124-9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61236-2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-148-1-200801010-00190"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.10.1056"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000026298.00663.58"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000161880.59963.da"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.9.3072"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/15.6.313"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7274.1440"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.13.6.741"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1993.00410050036006"},{"issue":"9362","key":"e_1_2_8_22_1","first-page":"1060","article-title":"Prospective Studies Collaboration. 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