{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:36:38Z","timestamp":1790516198946,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated the function of perivascular adipose tissue (PVAT) on vascular contractility within resistant arteries in high\u2010fat diet induced obese rats after long\u2010term aerobic exercise. Male Sprague\u2010Dawley rats were subjected to normal diet control group (N\u2010CTRL), normal diet exercise group (N\u2010EX), high\u2010fat diet control group (H\u2010CTRL), and high\u2010fat diet exercise group (H\u2010EX) (n\u00a0=\u00a08 in each group). After intervention, adipose tissues morphology was observed. Vasomotor function of mesenteric arteries with or without PVAT were assessed; mesenteric PVAT isolated from each group were transferred to chambers bath with untreated vessels (without PVAT) to evaluate the independent effect. Isolated PVAT was further pre\u2010treated with inhibitor of cystathionine\u2010\u03b3\u2010lyase (CSE), a key hydrogen sulphide (H<jats:sub>2<\/jats:sub>S) enzyme. Results showed that the size of lipid droplet around mesenteric arteries from H\u2010EX was significantly reduced (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05); uncoupling protein1 (UCP1) in PVAT from H\u2010EX was enhanced. In N\u2010CTRL, N\u2010EX, and H\u2010EX, vessels without PVAT showed higher sensitivity to serotonin (5\u2010HT) than that with intact PVAT. Vascular tension by 5\u2010HT was significantly reduced in H\u2010EX than H\u2010CTRL (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) in vessels with PVAT. Transferred PVAT from H\u2010EX compared with H\u2010CTRL significantly reduced vascular sensitivity to 5\u2010HT (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), and this effect was eliminated through inhibiting CSE. In summary, the anti\u2010contractile effect of PVAT on resistance artery was impaired in obesity but restored by long\u2010term aerobic exercise. The function of PVAT modified by obesity or by exercise has an independent influence on vascular reactivity, and PVAT derived H<jats:sub>2<\/jats:sub>S may participate in this process.<\/jats:p>","DOI":"10.1111\/1440-1681.13404","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T10:24:30Z","timestamp":1600943070000},"page":"697-703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Dysfunction of perivascular adipose tissue in mesenteric artery is restored by aerobic exercise in high\u2010fat diet induced obesity"],"prefix":"10.1111","volume":"48","author":[{"given":"Jingwen","family":"Liao","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Sports and Health Promotion Scientific Research Center Guangzhou Sport University Guangzhou 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