{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:37:49Z","timestamp":1772159869261,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The impact of androgens on the thyroid in women is poorly understood. The aim of the present study was to investigate whether vitamin D\/dehydroepiandrosterone (DHEA) combination therapy is superior to vitamin D alone in affecting thyroid autoimmunity and hypothalamic\u2013pituitary\u2013thyroid axis activity in young women with autoimmune thyroid disease. The study included 35 euthyroid women with untreated Hashimoto's thyroiditis and reduced sexual drive, allocated to one of two treatment groups. The first group (n\u00a0=\u00a019) received both vitamin D and DHEA, while the second (n\u00a0=\u00a016) was treated with only vitamin D. Serum thyroid antibody titres and concentrations of thyrotropin, free thyroid hormones, dehydroepiandrosterone\u2010sulphate (DHEA\u2010S), 25\u2010hydroxyvitamin D, testosterone and estradiol were measured at baseline and 6\u00a0months later. Vitamin D administered alone or in combination with DHEA decreased serum titres of thyroid peroxidase and thyroglobulin antibodies, which correlated with baseline antibody titres, baseline 25\u2010hydroxyvitamin D levels and treatment\u2010induced increase in 25\u2010hydroxyvitamin D levels. Apart from a stronger effect on antibody titres, vitamin D\/DHEA combination therapy slightly decreased thyrotropin levels, as well as increased DHEA\u2010S and testosterone levels. In this group of women, treatment\u2010induced changes in antibody titres and thyrotropin levels correlated with the impact on DHEA\u2010S and testosterone. The obtained results suggest that vitamin D\/DHEA combination therapy may be a better treatment option for euthyroid women with Hashimoto's thyroiditis than vitamin D alone.<\/jats:p>","DOI":"10.1111\/1440-1681.13410","type":"journal-article","created":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T14:04:52Z","timestamp":1601647492000},"page":"195-202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dehydroepiandrosterone potentiates the effect of vitamin D on thyroid autoimmunity in euthyroid women with autoimmune thyroiditis: A pilot study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5454-2620","authenticated-orcid":false,"given":"Robert","family":"Krysiak","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Pharmacology Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Witold","family":"Szkr\u00f3bka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Pharmacology Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogus\u0142aw","family":"Okopie\u0144","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Pharmacology Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-30726-3_17"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3280113d1a"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32832cf824"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0200"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2010.73"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7042485"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2015.214"},{"key":"e_1_2_10_9_1","first-page":"222","article-title":"Is vitamin D related to pathogenesis and treatment of Hashimoto's thyroiditis?","volume":"18","author":"Mazokopakis EE","year":"2015","journal-title":"Hell J Nucl Med"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-123038"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0856-1044"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0661"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-012-2386-4"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000175843"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12987"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.13046"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(90)90484-3"},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/bs.vh.2018.01.023","article-title":"DHEA modulates immune function: a review of evidence","volume":"108","author":"Prall SP","year":"2018","journal-title":"Vitam Horm"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2018.02.002"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2013.800040"},{"issue":"1","key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.33549\/physiolres.931496","article-title":"Immunoprotective steroids and SHBG in non\u2010treated hypothyroidism and their relationship to autoimmune thyroid disorders","volume":"57","author":"Drbalov\u00e1 K","year":"2008","journal-title":"Physiol Res"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.22.5.0441"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.126284"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2018.10.012"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.080663"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2704"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000381543"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2016.00057"},{"key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1055\/a-0653-7108","article-title":"The effect of gluten\u2010free diet on thyroid autoimmunity in drug\u2010na\u00efve women with Hashimoto's thyroiditis: a pilot study","volume":"127","author":"Krysiak R","year":"2019","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2018.12.006"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03534.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12956"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2017.1279141"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2015.12.033"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2019.04.010"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)02984-9"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/03602530600569877"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000081408.57952.22"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2006.26.34"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2986"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1385\/BTER:108:1-3:001"},{"key":"e_1_2_10_43_1","first-page":"156","article-title":"Work of the Polish council for control of iodine deficiency disorders, and the model of iodine prophylaxis in Poland","volume":"63","author":"Szybi\u0144ski Z","year":"2012","journal-title":"Endokrynol Pol"},{"key":"e_1_2_10_44_1","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1111\/j.1743-6109.2010.01871.x","article-title":"Sexual desire and the female sexual function index (FSFI): a sexual desire cutpoint for clinical interpretation of the FSFI in women with and without hypoactive sexual desire disorder","volume":"7","author":"Gerstenberger EP","year":"2010","journal-title":"Sex Med"},{"key":"e_1_2_10_45_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/009262300278597","article-title":"The Female Sexual Function Index (FSFI): a multidimensional self\u2010report instrument for the assessment of female sexual function","volume":"26","author":"Rosen R","year":"2015","journal-title":"J Sex Marital Ther"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.13410","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1440-1681.13410","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.13410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T11:23:02Z","timestamp":1693740182000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.13410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,16]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/1440-1681.13410"],"URL":"https:\/\/doi.org\/10.1111\/1440-1681.13410","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/1440-1681.13410\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/1440-1681.13410\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/1440-1681.13410\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/1440-1681.13410\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/1440-1681.13410\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/1440-1681.13410\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/1440-1681.13410\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/1440-1681.13410\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/1440-1681.13410\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/1440-1681.13410\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/1440-1681.13410\/v2\/review2","asserted-by":"object"}]},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"value":"0305-1870","type":"print"},{"value":"1440-1681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,16]]},"assertion":[{"value":"2020-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}