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The aim of this study was to investigate the impact of CUR, as a natural anti\u2010inflammatory agent, on neuro\u2010inflammation related to depression and compare it with the effects of fluoxetine (FLX) and estradiol (E\n                    <jats:sub>2<\/jats:sub>\n                    ) in ovariectomized (OVX) rats. The experimental animals were divided into the following five treatment groups (n\u00a0=\u00a010): sham\u2010operated, OVX, OVX\u2010E\n                    <jats:sub>2<\/jats:sub>\n                    (100\u00a0\u03bcg\/kg, im, every other day), OVX\u2010FLX (20\u00a0mg\/kg, ip, daily), and OVX\u2010CUR (100\u00a0mg\/kg, po, daily). The results indicated that CUR improved the animals\u2019 performances in the open field test and modulated dopamine (DA) and norepinephrine levels in several brain regions compared with the OVX group. CUR resulted in the down\u2010regulation of monoamine oxidase b and up\u2010regulation of tyrosine hydroxylase, as well asDA receptor mRNA in the limbic region. In addition, CUR significantly attenuated the production of serum corticosterone hormone, tumour necrosis factor\u2010alpha, interleukin\u2010\u03b21, interleukin\u20106, and nitric oxide in the limbic system. Furthermore, CUR normalized malondialdehyde levels and led to a significant upsurge in total antioxidant capacity, compared with the OVX group. Consequently, CUR, besides being harmless, was efficient against inflammation and oxidative\u2013nitrosative stress, showing a greater effect on DA receptor expression than FLX and E\n                    <jats:sub>2<\/jats:sub>\n                    in OVX rats.\n                  <\/jats:p>","DOI":"10.1111\/1440-1681.13427","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T15:37:05Z","timestamp":1603553825000},"page":"337-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Neuromodulatory effect of curcumin on catecholamine systems and inflammatory cytokines in ovariectomized female rats"],"prefix":"10.1111","volume":"48","author":[{"given":"Nashwa M.","family":"Saied","sequence":"first","affiliation":[{"name":"Department of Hormone National Organization for Drug Control and Research Giza 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