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The study population (n\u00a0=\u00a061) consisted of three matched groups of women with atherogenic dyslipidaemia: vitamin D\u2010na\u00efve women with\u00a0vitamin D\u00a0insufficiency (group A), women receiving vitamin D preparations because of\u00a0vitamin D\u00a0deficiency (group B), as well as vitamin D\u2010na\u00efve women with normal\u00a0vitamin D\u00a0status (group C), who were treated with micronized fenofibrate (200\u00a0mg daily). Glucose homeostasis markers, plasma lipids, as well as plasma levels of 25\u2010hydroxyvitamin D, uric acid, high\u2010sensitivity C\u2010reactive protein (hsCRP), fibrinogen and homocysteine were determined at the beginning of the study and 6\u00a0months later. At entry, group A was characterized by lower levels of 25\u2010hydroxyvitamin D, reduced insulin sensitivity and higher concentrations of uric acid, hsCRP, fibrinogen and homocysteine. Apart from a weaker effect on HDL\u2010cholesterol and triglycerides in group A, there were no differences between the treatment arms in the effect of fenofibrate on plasma lipids. However, only in groups B and C the drug improved insulin sensitivity and reduced circulating levels of uric acid and hsCRP, as well as increased levels of 25\u2010hydroxyvitamin D and these effects correlated with the degree of improvement in insulin sensitivity. Treatment\u2010induced increase in homocysteine was observed only in group A. The results of the study indicate that cardiometabolic effects of\u00a0fibrates may depend on the\u00a0vitamin D\u00a0status of patients<\/jats:p>","DOI":"10.1111\/1440-1681.13428","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T15:46:03Z","timestamp":1603554363000},"page":"186-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The impact of vitamin D status on cardiometabolic effects of fenofibrate in women with atherogenic dyslipidemia"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5454-2620","authenticated-orcid":false,"given":"Robert","family":"Krysiak","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Pharmacology Medical University of Silesia  Katowice 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