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Owing to its pharmacological profile and vasodilating action, nebivolol (N) is useful in MI. The aim of the present study was to assess in rat whether early nebivolol treatment could be beneficial in MI. It remains unknown whether \u03b2\u2010blockers are useful and safe in acute MI. On day (D) 0, male Sprague\u2010Dawley rats underwent left coronary artery ligation (MI) or simple thoracotomy (SHAM). On D1 and D2, the rats were treated with either nebivolol (5\u00a0mg.kg<jats:sup>\u22121<\/jats:sup>.day<jats:sup>\u22121<\/jats:sup>, MI\u2010N and Sham\u2010N) or vehicle (V, MI\u2010V and Sham\u2010V). On D3, heart rate, left ventricle (LV) intrinsic contractility (PESmid) and arterial elastance were measured. Cardiac and aortic \u03b2\u2010Adrenoceptor (AR) subtype mRNA were quantified using real time quantitative RT\u2010qPCR. Catecholamine response was assessed on isolated heart and aortic rings with isoproterenol. PESmid was decreased in MI without worsening the decrease nebivolol. In LV, \u03b2<jats:sub>1<\/jats:sub>\u2010 and \u03b2<jats:sub>3<\/jats:sub>\u2010AR mRNA were respectively decreased and increased in all MI. \u03b2<jats:sub>3<\/jats:sub>\u2010AR mRNA increase was partly limited by nebivolol. Ex vivo, basal contractility was less decreased in MI\u2010N than in MI\u2010V. Isoproterenol response was only altered in MI\u2010V. In MI aorta, Nebi prevented \u03b2<jats:sub>2<\/jats:sub>\u2010 and \u03b2<jats:sub>3<\/jats:sub>\u2010AR mRNA increases. In addition, Acetylcholine\u2010induced relaxation was lowered in MI\u2010V but preserved with nebivolol. We demonstrated an early modulation of cardiovascular \u03b2<jats:sub>3<\/jats:sub>\u2010AR transcription early MI. Despite its putative negative inotropic properties, nebivolol did not worsen cardiac function in basal conditions and preserved LV catecholamine response.<\/jats:p>","DOI":"10.1111\/1440-1681.13447","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T14:59:11Z","timestamp":1607957951000},"page":"1007-1015","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early nebivolol treatment is beneficial in myocardial infarction in rats partly through \u03b23\u2010adrenoceptor remodelling"],"prefix":"10.1111","volume":"48","author":[{"given":"Leslie","family":"Audigane","sequence":"first","affiliation":[{"name":"L'institut du thorax INSERM CNRS CHU Nantes Nantes UNIV Nantes  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Persello","sequence":"additional","affiliation":[{"name":"L'institut du thorax INSERM CNRS CHU Nantes Nantes UNIV Nantes  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