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Carnitine is a potent endogenous antioxidant and cellular fatty acid transporter for antioxidative stress and energy production in the cardiovascular system. The current study aimed to find the role of carnitine in the regulation of hypoglycaemia\u2010induced hypertension and cardiac hypertrophy. Male rats received insulin glargine (InG) to induce hypoglycaemia followed by D\u2010carnitine or acetyl\u2010L\u2010carnitine for carnitine depletion or carnitine supplementation, respectively. The obtained results showed that carnitine deficiency provoked hypoglycaemia\u2010induced hypertension. Mean arterial pressure was elevated from 78.16\u00a0\u00b1\u00a011.4 to 100\u00a0\u00b1\u00a05.11\u00a0mm\u00a0Hg in InG treated group, and from 78.2\u00a0\u00b1\u00a08.5 to 123.4\u00a0\u00b1\u00a028.2\u00a0mm\u00a0Hg in InG\u00a0+\u00a0D\u2010carnitine treated group. Acetyl\u2010L\u2010carnitine resisted the elevation in blood pressure in all hypoglycaemic animals and kept it within the normal values (68.33\u00a0\u00b1\u00a06.7\u00a0mm\u00a0Hg). Acetyl\u2010L\u2010carnitine increased myocardial carnitine content leading to the attenuation of hypoglycaemia\u2010induced oxidative stress, which was evaluated through measurement of the oxidative stress biomarkers such as inducible nitric oxide synthase, NAD(P)H quinone dehydrogenase\u20101, heme oxygenase\u2010I, and glutathione S\u2010transferase. Moreover, acetyl\u2010L\u2010carnitine prevented induction of gene expression of cardiac hypertrophy markers during hypoglycaemic conditions, which was assessed via the evaluation of mRNA expression of \u03b1\u2010myosin heavy chain and \u03b2\u2010myosin heavy chain. These findings demonstrate that carnitine might play an essential role in prevention of hypoglycaemia\u2010induced hypertension and cardiac hypertrophy through providing energy and antioxidants to the cardiovascular system.<\/jats:p>","DOI":"10.1111\/1440-1681.13455","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T00:31:13Z","timestamp":1609115473000},"page":"478-489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of carnitine in regulation of blood pressure (MAP\/SBP) and gene expression of cardiac hypertrophy markers (\u03b1\/\u03b2\u2010MHC) during insulin\u2010induced hypoglycaemia: Role of oxidative stress"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2761-004X","authenticated-orcid":false,"given":"Wael A.","family":"Alanazi","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology College of 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