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The toxic metabolites of CP are suggested to be responsible for oxidative stress resulted from the production of reactive oxygen species (ROS) and stimulation of lipid peroxidation. Nebivolol (NEB) is a third\u2010generation selective B<jats:sub>1<\/jats:sub> adrenoceptor antagonist, but it has also various pharmacological properties such as anti\u2010inflammation, anti\u2010apoptotic, and antioxidant activities. Thus, the present study aims to explore the potential protective effect of NEB against CP\u2010induced nephrotoxicity. A cumulative dose of CP (75\u00a0mg\/kg) was administered to albino rats by intraperitoneal injection. The protective effect of NEB was investigated by co\u2010administration of NEB (10\u00a0mg\/kg orally daily). Administration of NEB with CP significantly improved renal functions and reduced the oxidative renal changes induced by CP injection. Co\u2010administration of NEB ameliorated apoptosis and inflammatory markers that were markedly exaggerated by CP. Our results indicated that NEB could be used as a protective agent against CP\u2010induced nephrotoxicity.<\/jats:p>","DOI":"10.1111\/1440-1681.13481","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T10:27:22Z","timestamp":1613644042000},"page":"811-819","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Nebivolol protects against cyclophosphamide\u2010induced nephrotoxicity through modulation of oxidative stress, inflammation, and apoptosis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7109-939X","authenticated-orcid":false,"given":"Hanaa","family":"Wanas","sequence":"first","affiliation":[{"name":"Department of Medical Pharmacology Faculty of Medicine Cairo University Cairo Egypt"},{"name":"Department of Toxicology and Pharmacology Faculty of Pharmacy Taibah University Madinah Saudi 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