{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:04:39Z","timestamp":1790960679006,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>One\u2010lung ventilation (OLV), a common ventilation technique, is associated with perioperative lung injury, tightly connected with inflammatory responses. Dexmedetomidine has shown positive anti\u2010inflammatory effects in lung tissues in pre\u2010clinical models. This study investigated the efficacy of dexmedetomidine for suppressing inflammatory responses in patients requiring OLV. We searched PubMed, MEDLINE, Embase, Scopus, Ovid, and Cochrane Library for randomized controlled trials focusing on dexmedetomidine\u2019s anti\u2010inflammatory effects on patients requiring OLV without any limitation on the year of publication or languages. 20 clinical trials were assessed with 870 patients in the dexmedetomidine group and 844 in the control group. Our meta\u2010analysis investigated the anti\u2010inflammatory property of dexmedetomidine perioperatively [T1 (30\u2010min OLV), T2 (90\u2010min OLV), T3 (end of surgery) and T4 (postoperative day 1)], demonstrating that dexmedetomidine\u2019s intraoperative administration resulted in a significant reduction in serum concentration of interleukin\u20106, tumor necrosis factor\u2010\u03b1 and other inflammatory cytokines perioperatively. By calculating specific <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> index, significant heterogeneity was observed on all occasions, with <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> index ranging from 95% to 99%. For IL\u20106 changes, sensitivity analysis showed that the exclusion of a single study led to a significant decrease of heterogeneity (96%\u20130%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.00001). Besides, pulmonary oxygenation was ameliorated in the dexmedetomidine group comparing with the control group. In conclusion, perioperative administration of dexmedetomidine can attenuate OLV induced inflammation, ameliorate pulmonary oxygenation, and may be conducive to a decreased occurrence of postoperative complications and better prognosis. However, the results should be prudently interpreted due to the evidence of heterogeneity and the limited number of studies.<\/jats:p>","DOI":"10.1111\/1440-1681.13525","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T09:01:10Z","timestamp":1622106070000},"page":"1203-1214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Dexmedetomidine attenuates one\u2010lung ventilation associated lung injury by suppressing inflammatory responses: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"48","author":[{"given":"Yun\u2010Xiao","family":"Bai","sequence":"first","affiliation":[{"name":"College of Anesthesiology Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie\u2010Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing\u2010Cheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke\u2010Xuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Wu","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Tangshan Maternity and Child Health Care Hospital Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e3283346c6d"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31819fb15d"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000808"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.1.9803046"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu054"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.1.9604014"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208707"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119259"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.1.54"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155224"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104290"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/939431"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep12342"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/186736"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6136105"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2018.2400"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-4597(09)60002-3"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11612"},{"issue":"2","key":"e_1_2_8_20_1","first-page":"1219","article-title":"Effects of dexmedetomidine on oxidative stress and inflammatory response in lungs during mechanical ventilation in COPD rats","volume":"19","author":"Li P","year":"2020","journal-title":"Exp Ther Med"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.09.018"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2010.02.020"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3954"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001114"},{"issue":"36","key":"e_1_2_8_25_1","first-page":"2929","article-title":"Effect of dexmedetomidine on perioperative inflammatory response and cellular immune in patients undergoing radical operation of thoracoscopic lung cancer","volume":"98","author":"Kong L","year":"2018","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"10","key":"e_1_2_8_26_1","first-page":"2544","article-title":"Effect of dexmedetomidine on perioperative inflammation and lung protection in elderly patients undergoing radical resection of lung cancer","volume":"13","author":"Xie Y","year":"2020","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"e_1_2_8_27_1","first-page":"37","article-title":"Effects of dexmedetomidine on injury of lungs and CHOP protein expression in elderly patients with lung cancer during one\u2010lung ventilation","volume":"100","author":"Liu GC","year":"2020","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"12","key":"e_1_2_8_28_1","first-page":"1673","article-title":"Protective effect of dexmedetomidine against perioperative inflammation and on pulmonary function in patients undergoing radical resection of lung cancer","volume":"37","author":"Guo YB","year":"2017","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"issue":"6","key":"e_1_2_8_29_1","first-page":"2879","article-title":"Clinical application and effect of dexmedetomidine in combination with continuous positive airway pressure on one\u2010lung ventilation in lung surgery of elder patients","volume":"31","author":"Lin J","year":"2018","journal-title":"Pak J Pharm Sci"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8638301"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2575910"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-018-0532-6"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2020.94944"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4976205"},{"issue":"7","key":"e_1_2_8_35_1","first-page":"1013","article-title":"Dexmedetomidine combined with protective lung ventilation strategy provides lung protection in patients undergoing radical resection of esophageal cancer with one\u2010lung ventilation","volume":"40","author":"Gong Z","year":"2020","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"issue":"3","key":"e_1_2_8_36_1","first-page":"3144","article-title":"Effects of dexmedetomidine pretreatment on heme oxygenase\u20101 expression and oxidative stress during one\u2010lung ventilation","volume":"8","author":"Gao S","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12530"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118249"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S276005"},{"issue":"20","key":"e_1_2_8_40_1","first-page":"2834","article-title":"Influence of the dexmedetomidine combined with parecoxib sodium on inflammatory factor","volume":"23","author":"Yang Q","journal-title":"J Hainan Med Univ"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-019-01299-7"},{"issue":"01","key":"e_1_2_8_42_1","first-page":"97","article-title":"Effect of dexmedetomidine combined with continuous positive airway pressure on oxidative stress and inflammatory responses in elderly patients undergoing chest operation","volume":"37","author":"Zhang JC","year":"2016","journal-title":"Med J Wuhan Univ"},{"issue":"11","key":"e_1_2_8_43_1","first-page":"1844","article-title":"Effects of dexmedetomidine with sevoflurane on lung injury in patients with one\u2010lung ventilation","volume":"48","author":"Luo JJ","year":"2019","journal-title":"Chongqing Med"},{"issue":"2","key":"e_1_2_8_44_1","first-page":"1301","article-title":"Application value of conventional anesthesia combined with dexmedetomidine in thoracoscopic radical resection of lung cancer","volume":"14","author":"Pi Y","year":"2021","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.07.027"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2690-4"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.006"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_8_49_1","volume-title":"Cochrane handbook for systematic reviews of interventions. Version 5.1.0 (Updated March 2011). Cochrane handbook for systematic reviews of interventions","author":"Higgins JPT"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002864"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01366"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"e_1_2_8_53_1","unstructured":"GetData Graph Digitizer. https:\/\/getdata\u2010graph\u2010digitizer.com\/index.php"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.13525","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1440-1681.13525","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.13525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:30:54Z","timestamp":1693355454000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.13525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,14]]},"references-count":52,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/1440-1681.13525"],"URL":"https:\/\/doi.org\/10.1111\/1440-1681.13525","archive":["Portico"],"relation":{},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"value":"0305-1870","type":"print"},{"value":"1440-1681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,14]]},"assertion":[{"value":"2021-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}