{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:22:15Z","timestamp":1747182135229,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T00:00:00Z","timestamp":1624838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The intrarenal dopamine system has been thoroughly investigated at all levels, especially its role in salt\u2010dependent and other forms of hypertension. However, the evidence regarding dopamine's tonic influence on renal tubular transport of sodium remains equivocal. We reinvestigated its tonic influence on sodium excretion and systemic and renal haemodynamics. Early effects of dopamine D1 receptor blockade using 90\u2010min Schering 23390 (SCH) infusion were examined in anaesthetized rats on 7\u00a0days\u2019 high salt diet (HS), early uninephrectomized rats on 14\u00a0days\u2019 HS diet, drinking 1% saline (HS\/UNX), and in spontaneously hypertensive rats (SHR). In the HS group (baseline BP ~133\u00a0mm\u00a0Hg) renal intracortical SCH promptly decreased sodium, water and total solute excretion (U<jats:sub>Na<\/jats:sub>V, V, U<jats:sub>osm<\/jats:sub>V), with significant difference from the solvent\u2010infused group. BP and renal artery blood flow (RBF, Transonic probe) did not change. In HS\/UNX model (baseline BP ~150\u00a0mm\u00a0Hg), characterized by hypertrophy of the remaining kidney, the excretion parameters only tended to decrease whereas SCH induced an ~20% fall in RBF. In SHR (BP ~180\u00a0mm\u00a0Hg), U<jats:sub>Na<\/jats:sub>V and V tended to increase in solvent\u2010infused rats; this increasing tendency was abolished by SCH infusion. During experiments the renal vascular resistance increased significantly in SCH\u2010 and solvent\u2010infused SHR. Despite some contradictory findings regarding the genuine tonic control of renal excretion by intrarenal dopamine, our results clearly support such role in rats on HS diet and in SHR, the model resembling human essential hypertension. The observations strengthen the experimental basis and the rationale for targeting the intrarenal dopamine system in attempts to combat arterial hypertension.<\/jats:p>","DOI":"10.1111\/1440-1681.13529","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T11:16:36Z","timestamp":1622805396000},"page":"1280-1287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reinvestigation of the tonic natriuretic action of intrarenal dopamine: comparison of two variants of salt\u2010dependent hypertension and spontaneously hypertensive rats"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7717-2105","authenticated-orcid":false,"given":"Bo\u017cena","family":"B\u0105dzy\u0144ska","sequence":"first","affiliation":[{"name":"Department of Renal and Body Fluid Physiology Mossakowski Medical Research Institute Polish Academy of Sciences Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"Sadowski","sequence":"additional","affiliation":[{"name":"Department of Renal and Body Fluid Physiology Mossakowski Medical Research Institute Polish Academy of Sciences Warsaw 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