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In recent years, hydrogen sulphide (H<jats:sub>2<\/jats:sub>S) has arisen as a new gasotransmitter with an impact on endothelial function. However, the involvement of H<jats:sub>2<\/jats:sub>S in the pathophysiology of preeclampsia is not fully understood, and only a few studies with limited sample size have investigated circulating levels of H<jats:sub>2<\/jats:sub>S in preeclamptic patients. Moreover, H<jats:sub>2<\/jats:sub>S levels have not been previously evaluated in gestational hypertension. Furthermore, the relationship between H<jats:sub>2<\/jats:sub>S and NO in these hypertensive disorders of pregnancy has yet to be determined. We measured H<jats:sub>2<\/jats:sub>S levels in plasma of 120\u00a0healthy pregnant women, 88\u00a0gestational hypertensive and 62 preeclamptic women. We also measured plasma nitrite in a subset of patients and carried out correlation analysis between plasma H<jats:sub>2<\/jats:sub>S and nitrite in these three groups. We found that plasma H<jats:sub>2<\/jats:sub>S was elevated in preeclampsia and further increased in gestational hypertension compared to healthy pregnancy. Plasma nitrite was reduced in gestational hypertension and preeclampsia, and these levels were negatively correlated with H<jats:sub>2<\/jats:sub>S in both gestational hypertension and preeclampsia, but not in healthy pregnancy. Our results indicate that increases in H<jats:sub>2<\/jats:sub>S may represent a mechanism triggered as an attempt to compensate reduced NO in gestational hypertension and preeclampsia. Future studies are warranted to investigate the mechanisms underlying H<jats:sub>2<\/jats:sub>S\/NO interaction on mediating endothelial dysfunction in these hypertensive disorders of pregnancy.<\/jats:p>","DOI":"10.1111\/1440-1681.13534","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T08:55:36Z","timestamp":1622710536000},"page":"1224-1230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Circulating levels of hydrogen sulphide negatively correlate to nitrite levels in gestational hypertensive and preeclamptic pregnant women"],"prefix":"10.1111","volume":"48","author":[{"given":"Jose Sergio","family":"Possomato\u2010Vieira","sequence":"first","affiliation":[{"name":"Institute of Biosciences S\u00e3o Paulo State University \u2013 IBB\/UNESP Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina","family":"Palei","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Mississippi Medical Center Jackson MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Cristina","family":"Pinto\u2010Souza","sequence":"additional","affiliation":[{"name":"Institute of Biosciences S\u00e3o Paulo State University \u2013 IBB\/UNESP Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Cavalli","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Faculty of Medicine of Ribeirao Preto University of Sao Paulo Ribeirao Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alan","family":"Dias\u2010Junior","sequence":"additional","affiliation":[{"name":"Institute of Biosciences S\u00e3o Paulo State University \u2013 IBB\/UNESP Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Sandrim","sequence":"additional","affiliation":[{"name":"Institute of Biosciences S\u00e3o Paulo State University \u2013 IBB\/UNESP Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7]]},"reference":[{"issue":"5","key":"e_1_2_8_2_1","first-page":"1122","article-title":"Hypertension in pregnancy. 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