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Recent studies showed that the expression and functional changes of uric acid transporters, including URAT1, GLUT9 and ABCG2, were associated with HU. Moreover, a large number of genome\u2010wide association studies have shown that these transporters\u2019 dysfunction leads to HU. In this review, we describe the recent progress of aetiology and related transporters of HU, and we also summarise the common co\u2010morbidities possible mechanisms, as well as the potential pharmacological and non\u2010pharmacological treatment methods for HU, aiming to provide new ideas for the treatment of HU.<\/jats:p>","DOI":"10.1111\/1440-1681.13539","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T17:46:25Z","timestamp":1623865585000},"page":"1305-1316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["An update of genetics, co\u2010morbidities and management of hyperuricaemia"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4719-4052","authenticated-orcid":false,"given":"Chunsheng","family":"Zhu","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Zhengzhou University Zhengzhou 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