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ER stress, reflected by protein unfolding and calcium handling abnormalities, has been studied as a pathogenic factor in cardiovascular diseases. The aim of this study is to examine the effects of ER stress on mechanical and electrophysiological functions in the heart and explore the underlying molecular mechanisms. A total of 30 rats were randomly divided into control, ER stress inducer (tunicamycin[TN]) and ER stress inhibitor (tunicamycin+4\u2010phenylbutyric acid [4\u2010PBA]) groups. ER stress induction led to significantly systolic and diastolic dysfunction as reflected by maximal increasing\/decreasing rate of left intraventricular pressure (\u00b1dp\/dt), left ventricular peaksystolic pressure(LVSP) and LV end\u2010diastolic pressure(LVEDP). Epicardial mapping performed in vivo revealed reduced conduction velocity and increased conduction heterogeneity associated with the development of spontaneous ventricular tachycardia. Masson\u2019s trichrome staining revealed marked fibrosis in the myocardial interstitial and sub\u2010pericardial regions, and thickened epicardium. Western blot analysis revealed increased pro\u2010fibrotic factor transforming growth factor\u2010\u03b21 (TGF\u2010\u03b21), decreased mitochondrial biogenesis protein peroxlsome proliferator\u2010activated receptor\u2010\u03b3 coactlvator\u20101\u03b1 \uff08PGC\u20101a\uff09, and decreased mitochondrial fusion protein mitofusin\u20102 (MFN2). These changes were associated with mitochondria dysfunction and connexin 43(CX43)translocation to mitochondria. These abnormalities can be partially prevented by the ER stress inhibitor 4\u2010PBA. Our study shows that ER stress induction can produce cardiac electrical and mechanism dysfunction as well as structural remodelling. Mitochondrial function alterations are contributed by CX43 transposition to mitochondria. These abnormalities can be partially prevented by the ER stress inhibitor 4\u2010PBA.<\/jats:p>","DOI":"10.1111\/1440-1681.13541","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T17:52:17Z","timestamp":1623865937000},"page":"1371-1381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cardiac abnormalities after induction of endoplasmic reticulum stress are associated with mitochondrial dysfunction and connexin43 expression"],"prefix":"10.1111","volume":"48","author":[{"given":"Jinli","family":"He","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengqi","family":"Gong","sequence":"additional","affiliation":[{"name":"Tianjin 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