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The development of new pharmacological therapies has focused on novel plant\u2010derived phytochemicals. The alcoholic monoterpene myrtenol has been isolated from several plant species, and has anxiolytic, analgesic, anti\u2010inflammatory and antioxidant actions. Our study evaluated the neuroprotective potential of myrtenol complexed with \u03b2\u2010cyclodextrin (MYR) on a progressive parkinsonism model induced by reserpine (RES) in mice. The complexation with cyclodextrins enhances the pharmacological action of monoterpenes. Male Swiss mice were treated daily with MYR (5\u00a0mg\/kg, p.o.) and with RES (0.1\u00a0mg\/kg, s.c.) every other day during 28\u00a0days. Behavioural evaluations were conducted across treatment. At the end of the treatment, immunohistochemistry for tyrosine hydroxylase (TH) and oxidative stress parameters were evaluated. Chronic MYR\u2010treatment protected against olfactory sensibility loss, restored short\u2010term memory and decreased RES\u2010induced motor impairments. Moreover, this treatment prevented dopaminergic depletion and reduced the oxidative status index in the dorsal striatum. Therefore, MYR ameliorated motor and non\u2010motor impairments in the progressive animal model of parkinsonism, possibly by an antioxidant action. Additional research is needed to investigate the mechanisms involved in this neuroprotective effect.<\/jats:p>","DOI":"10.1111\/1440-1681.13563","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T09:24:15Z","timestamp":1628155455000},"page":"1488-1499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Myrtenol complexed with \u03b2\u2010cyclodextrin ameliorates behavioural deficits and reduces oxidative stress in the reserpine\u2010induced animal model of Parkinsonism"],"prefix":"10.1111","volume":"48","author":[{"given":"Suellen","family":"Silva\u2010Martins","sequence":"first","affiliation":[{"name":"Departament of Biosciences Universidade Federal de S\u00e3o Paulo Santos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Ivo Ara\u00fajo","family":"Beserra\u2010Filho","sequence":"additional","affiliation":[{"name":"Departament of Biosciences Universidade 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